(SuperStar[])(Subscript[AUC, tot   ratio])=((Total   AUC   of   parent   IVadministration   of   Prodrug)/(Total   AUC   of   parent   after   IVadministration   of   parent   (historic   data)))(^( ** ))(Subscript[AUC, tot   ratio])=((Total   AUC   of   parent   POadministration   of   Prodrug)/(Total   AUC   of   parent   after   POadministration   of   parent   (historic   data)))