U.S. patent application number 14/356775 was filed with the patent office on 2014-09-25 for bipyridine triazole type rare earth complex and preparation method thereof.
This patent application is currently assigned to GUANGDONG SYNYOO NEW MATERIAL CO., LTD.. The applicant listed for this patent is GUANGDONG SYNYOO NEW MATERIAL CO., LTD.. Invention is credited to Hangbing Fang, Dong Liang, Shangen Ning, Huahong Shi, Jiguo Song.
Application Number | 20140288305 14/356775 |
Document ID | / |
Family ID | 48057348 |
Filed Date | 2014-09-25 |
United States Patent
Application |
20140288305 |
Kind Code |
A1 |
Shi; Huahong ; et
al. |
September 25, 2014 |
BIPYRIDINE TRIAZOLE TYPE RARE EARTH COMPLEX AND PREPARATION METHOD
THEREOF
Abstract
A bipyridine triazole rare earth complex LnL.sub.3 as shown in
Formula 1 and a preparation method thereof. The rare earth complex
has high thermal stability and is suitable for manufacturing
devices by an evaporation film-forming process or manufacturing
devices by a solution film-forming process. The preparation method
has the advantages of high yield, good product purity, short
reaction time and simplicity in operation, and can greatly reduce
cost. ##STR00001## ##STR00002##
Inventors: |
Shi; Huahong; (Foshan City,
CN) ; Song; Jiguo; (Foshan City, CN) ; Fang;
Hangbing; (Foshan City, CN) ; Liang; Dong;
(Foshan City, CN) ; Ning; Shangen; (Foshan City,
CN) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
GUANGDONG SYNYOO NEW MATERIAL CO., LTD. |
Foshan City, Guangdong Province |
|
CN |
|
|
Assignee: |
GUANGDONG SYNYOO NEW MATERIAL CO.,
LTD.
Foshan City, Guangdong Province
CN
GUANGDONG SYNYOO NEW MATERIAL CO., LTD.
Foshan City, Guangdong Province
CN
|
Family ID: |
48057348 |
Appl. No.: |
14/356775 |
Filed: |
June 17, 2013 |
PCT Filed: |
June 17, 2013 |
PCT NO: |
PCT/CN2013/077288 |
371 Date: |
May 7, 2014 |
Current U.S.
Class: |
546/2 |
Current CPC
Class: |
C07F 5/003 20130101;
C07D 401/14 20130101 |
Class at
Publication: |
546/2 |
International
Class: |
C07F 5/00 20060101
C07F005/00 |
Foreign Application Data
Date |
Code |
Application Number |
Jun 28, 2012 |
CN |
201210219952.3 |
Jan 8, 2013 |
CN |
201310006548.2 |
Claims
1. A bipyridine triazole type rare earth complex LnL.sub.3,
represented by structural formulas as shown in Formula 1:
##STR00032## ##STR00033## wherein R.sub.1 is hydrogen, halogen, an
alkane group or an aromatic hydrocarbon group; R.sub.2 is hydrogen,
halogen, an alkane group or an aromatic hydrocarbon group; R.sub.3
is hydrogen, halogen, methyl, trifluoromethyl or phenyl; and
central rare earth ion Ln is any one of yttrium, lanthanum, cerium,
praseodymium, neodymium, samarium, europium, gadolinium, terbium,
dysprosium, holmium, erbium, thulium, ytterbium and lutetium.
2. A preparation method of the bipyridine triazole type rare earth
complex according to claim 1 comprising: a) oxidizing a bipyridine
derivative represented by Formula 2 by an oxidant to generate a
bipyridine type nitrogen oxide; ##STR00034## b) performing a
cyano-substitution reaction on the bipyridine type nitrogen oxide
to obtain a 6-cyano-bipyridine derivative; c) enabling the
6-cyano-bipyridine derivative to react with a hydrazine and a
carboxylic acid derivative for cyclization, thus obtaining a
bipyridine triazole type compound; and d) enabling a rare earth
metal salt to react with the bipyridine triazole type compound to
generate the bipyridine triazole type rare earth complex
LnL.sub.3.
3. The preparation method of the bipyridine triazole type rare
earth complex according to claim 2, wherein the oxidant in step a)
is a m-chloroperoxybenzoic acid or hydrogen peroxide solution; a
molar ratio of the oxidant to the bipyridine derivative is not less
than 1:1; a reaction temperature is between room temperature and
110.degree. C.; and a solvent is a carboxylic acid or an alkyl
halide.
4. The preparation method of the bipyridine triazole type rare
earth complex according to claim 2, wherein, in step b), a cyano
reagent is NaCN, KCN, CuCN, Zn(CN).sub.2 or (CH.sub.3).sub.3SiCN; a
reaction temperature is less than 80.degree. C.; and a reaction
time is 1 to 7 days.
5. The preparation method of the bipyridine triazole type rare
earth complex according to claim 2, wherein, in step c), the
hydrazine and a 6-cyano-2,2'-bipyridine derivative react in a mixed
solvent of alcohol and water in a volume ratio of 1:0 to 0:1 to
obtain a reactant, then the reactant reacts with a carboxylic acid,
an acid anhydride, an acyl chloride or an ester in a halogenated
alkane, ester, aromatic hydrocarbon, alcohol, acid or ether solvent
for cyclization, the amount of the hydrazine used is not less than
1.0 equivalent, the amount of the carboxylic acid, acid anhydride,
acyl chloride or ester used is not less than 1.0 equivalent; and a
reaction temperature ranges from room temperature to a reflux
temperature according to different reaction substrates.
6. The preparation method of the bipyridine triazole type rare
earth complex according to claim 2, wherein, in step c), a
6-cyano-2,2'-bipyridine derivative and an acylhydrazine directly
react in a halogenated alkane, ester, aromatic hydrocarbon,
alcohol, acid or ether solvent for cyclization; and a reaction
temperature ranges from room temperature to a reflux temperature
according to different reaction substrates.
7. The preparation method of the bipyridine triazole type rare
earth complex according to claim 2, wherein, in step d), the rare
earth metal salt is dissolved in water and dropped into a solution
of the bipyridine triazole type compound and a water-soluble
organic solvent of an alkali to start a reaction, a temperature is
controlled at 0.degree. C.-100.degree. C., the reaction is
continuously performed for 1 to 48 hours after the end of dropping,
and a product is filtered and recrystallized to obtain the
bipyridine triazole type rare earth complex LnL.sub.3.
8. The preparation method of the bipyridine triazole type rare
earth complex according to claim 7, wherein, the rare earth metal
salt is selected from chloride, bromide, fluoride, iodide, nitrate,
sulfate, perchlorate, phosphate, carboxylate, sulfonate,
fluoroborate and hexafluorophosphate of rare earth metals; the
amount of the rare earth metal salt used is 1.0 equivalent, the
amount of the bipyridine triazole derivative used is 2.0-4.0
equivalents, the alkali is an inorganic alkali or an organic
alkali, and the amount used is not less than 1.0 equivalent; and
the organic solvent is an alcohol.
Description
FIELD OF THE INVENTION
[0001] The invention relates to a novel bipyridine triazole type
rare earth complex and a preparation method thereof.
BACKGROUND OF THE INVENTION
[0002] China is exceptionally rich in resources to develop
applications of rare earth. In the currently ascertained rare earth
resources around the world, 80% of the rare earth resources exist
in China and the varieties are complete. In order to protect the
resources and avoid the environmental problems caused by excessive
development, China has began to manage and control the export of
rare earth ore since 2009, but this action was protested by
America, Japan, Europe and other countries. This reflects the
preciousness of the rare earth resources and the necessary and the
urgency in great development of deep processing of rare earth from
another perspective. Directed to rich and distinctive rare earth
resources in China, the optical materials which are the most
distinctive rare earth elements and have been well accumulated in
China are taken as the main development direction in the transition
of Chinese rare earth industry to high-tech functional material
industry, which per se also reflects the great industrial
development requirements of China.
[0003] Organic electroluminescence is self-luminescent and has
luminescent materials rich in colors for selection, and thus has
the advantages of high efficiency, high brightness (>10,000
cd/m.sup.2), high contrast (>1000:1), wide color gamut (>100%
NTSC), wide viewing angle (0-180.degree.), fast response
(microsecond grade) and the like in the properties of display and
luminescence; and furthermore, light, thin (less than 1 mm) and
flexible display is realized, and these performances exceed those
of all the existing display technologies, so that the organic
electroluminescence is generally acknowledged as the next
generation of flat panel display technologies and lighting
technologies.
[0004] Central luminescent ions of the rare earth complex can be
divided into visible region strongly-luminescent rare earth ions,
weakly-luminescent rare earth ions, rare earth ions with f-d
radiation transitions and visible region non-luminescent rare earth
ions. For example, Eu.sup.2+, Ce.sup.3+ and Tm.sup.3+ emit blue
light, Eu.sup.3+ emits red light, Tb.sup.3+ emits green light,
Sm.sup.3+ emits pink light, Dy.sup.3+ emits yellow light and
Nd.sup.3+, Er.sup.3+ and Yb.sup.3+ emit near-infrared light. The
radiation transitions of Tb.sup.3+ and Eu.sup.3+ fall within a
visible light region, and during research of luminescent materials
of the rare earth complex, the two types of ions attract the most
attention, wherein a main emission peak of Tb.sup.3+ is positioned
at about 545 nm and the color is very pure green; and the main
emission peak of Eu.sup.3+ is positioned at about 613 nm, and the
color is red with great eye sensitivity. The sensitized
luminescence property of the rare earth can be applied to OLED
display/lighting technologies in practices, biomedical test and
anti-counterfeiting label printing, as well as infrared
communication technologies. Since 1990, Kido team has firstly
proved that .beta.-diketone complexes of terbium can be used as
luminescent materials for OLED devices. As they have narrow
emission peaks and half-peak width of less than 10 nm, the chroma
is saturated and bright, and the photo-quantum efficiency of rare
earth organic luminescent materials is ultrahigh, the photo-quantum
efficiency of reported solid europium complexes can achieve 85%
(Coordination Chemistry Reviews, 2000, 196: 165), and the
development of the rare earth organic luminescent materials
re-attracts high attention of scientific community. The OLED
devices of the europium complexes can obtain red light with
saturated chroma; and the OLED devices of the terbium complexes can
obtain green light with pure chroma. However, the efficiency and
the service life of these devices fall far behind their theoretical
expectations. The main reasons comprise poor film-forming ability
of small molecular rare earth complexes, poor transmission
performance of a current carrier and poor electrical, optical and
thermal stability. As for other types of luminescent materials,
such as small molecular organic luminescent materials, high polymer
luminescent materials, complexes of precious metals, such as
iridium, platinum and gold, and the like, although the emission
peaks are wide, and the half-peak width is generally 80-100 nm, the
color is dim in comparison with the rare earth luminescent
materials; however, the efficiency and the service life of these
luminescent materials have achieved the practical requirements.
[0005] The rare earth element needs 9-coordination to achieve
saturated coordination; and simultaneously, as the rare earth metal
ions have positive charges, ligands need to have negative charges
to meet electrical neutrality. So far, the rare earth complex
luminescent materials have adopted mixed ligands, e.g.
1,10-phenanthroline, .beta.-diketone, and pyridine carboxylic acid
compounds as ligands or for providing negative charges.
[0006] Up till now, novel rare earth luminescent complexes which
are suitable for actual applications and even suitable for OLED
display and lighting technologies have not been reported.
SUMMARY OF THE INVENTION
[0007] The invention aims at providing a novel bipyridine triazole
rare earth complex. Another purpose of the invention is to provide
a preparation method of the novel bipyridine triazole type rare
earth complex.
[0008] The invention is implemented through the following technical
scheme:
[0009] The structural formulas of the bipyridine triazole type rare
earth complex LnL.sub.3 are as shown in formula 1:
##STR00003## ##STR00004##
wherein R.sub.1 is selected from hydrogen, halogen, an alkane group
or an aromatic hydrocarbon group; R.sub.2 is selected from
hydrogen, halogen, an alkane group or an aromatic hydrocarbon
group; R.sub.3 is selected from hydrogen, halogen, methyl,
trifluoromethyl or phenyl; and central rare earth ions Ln are
selected from any one of yttrium, lanthanum, cerium, praseodymium,
neodymium, samarium, europium, gadolinium, terbium, dysprosium,
holmium, erbium, thulium, ytterbium and lutetium. The synthesis
method of the bipyridine triazole type rare earth complex, provided
by the invention, comprises the following steps: a) oxidizing a
bipyridine derivative as shown in structural Formula 2 by an
oxidant to venerate a bipyridine type nitrogen oxide; b) performing
cyano-substitution on the bipyridine type nitrogen oxide to obtain
a 6-cyano-bipyridine derivative; c) enabling the 6-cyano-bipyridine
derivative to react with hydrazine and a carboxylic acid derivative
for cyclization, thus obtaining a bipyridine triazole type
compound; and d) enabling a rare earth metal salt to react with the
bipyridine triazole type compound to generate the bipyridine
triazole type rare earth complex LnL.sub.3.
##STR00005##
[0010] The reaction expression is as follows:
##STR00006##
[0011] As for the oxidation reaction in step a), the oxidant is
selected from m-chloroperoxybenzoic acid (m-CPBA) or hydrogen
peroxide solution; the molar ratio of the oxidant to the bipyridine
derivative is not less than 1:1; the reaction temperature is from
room temperature to 110.degree. C.; and a solvent is selected from
carboxylic acid or alkyl halide, and the minimal using amount of
the solvent needs to just dissolve the raw materials.
[0012] As for step b), a cyano (CN) reagent is selected from NaCN,
KCN, CuCN, Zn(CN).sub.2 or (CH.sub.3).sub.3SiCN (TMSCN,
trimethylsilyl cyanide); the reaction is temperature-sensitive, and
the temperature needs to be controlled to be less than 80.degree.
C.; and the reaction time is 1-7 days according to different
reaction substrates.
[0013] The reaction in step c) can be implemented by adopting the
following two ways:
(1) enabling the hydrazine to react with 6-cyano-2,2'-bipyridine
derivative in a mixed solvent of alcohol and water in the volume
ratio of 1:0 to 0:1, and then reacting with carboxylic acid, acid
anhydride, acyl chloride or ester in a halogenated alkane, ester,
aromatic hydrocarbon, alcohol, acid or ether solvent for
cyclization, wherein the using amount of the hydrazine is not less
than 1.0 equivalent, the using amount of the carboxylic acid, acid
anhydride, acyl chloride or ester is not less than 1.0 equivalent,
and the minimal using amount of the solvent is proper to be
sufficient to dissolve the raw material; and the reaction
temperature ranges from room temperature to reflux temperature
according to different reaction substrates; and (2) enabling the
6-cyano-2,2'-bipyridine derivative and acylhydrazine to react
directly in the halogenated alkane, ester, aromatic hydrocarbon,
alcohol, acid or ether solvent for cyclization, and the minimal
using amount is proper to be sufficient to dissolve the raw
material; and the reaction temperature ranges from room temperature
to reflux temperature according to different reaction
substrates.
[0014] Preferably, as for the reaction in step c), the
6-cyano-bipyridine derivative is firstly dissolved in an organic
solvent, the temperature is controlled at -20.degree. C. to
50.degree. C., the hydrazine and the carboxylic acid derivative,
which are dissolved in the organic solvent are dropped, the
reaction is further performed for 1-24 h after the end of dropping,
the product is crystallized, filtered and recrystallized to obtain
the bipyridine triazole type compound, and the organic solvent is
selected from ether, ester, aromatic hydrogen, alcohol,
acetonitrile or ketone.
[0015] As for the reaction in step d), the rare earth metal salt is
dissolved in water and dropped into a solution of the bipyridine
triazole type compound and a water-soluble organic solvent of an
alkali, the temperature is controlled at 0.degree. C.-100.degree.
C., the reaction is continuously performed for 1-48 h after the end
of dropping, and the product is filtered and recrystallized to
obtain the bipyridine triazole type rare earth complex LnL.sub.3;
and the organic ligand bipyridine triazole derivative firstly react
with the alkali and then the reactant is mixed with the rare earth
metal salt solution for reaction to obtain the bipyridine triazole
type rare earth complex.
[0016] The rare earth metal salt is selected from chloride,
bromide, fluoride, iodide, nitrate, sulfate, perchlorate,
phosphate, carboxylate, sulfonate, fluoroborate and
hexafluorophosphate; the using amount of the rare earth metal slat
is 1.0 equivalent, the using amount of the bipyridine triazole
derivative is 2.0-4.0 equivalents, preferably 3.0 equivalents, the
alkali is inorganic alkali or organic alkali, and the using amount
is not less than 1.0 equivalent; and the organic solvent can be
various alcohols selected from ROH, 2-ethoxyethanol,
2-methoxyethanol, 1,3-propanediol, 1,2-propanediol, ethylene glycol
or glycerol; and the volume ratio of the organic solvent to the
water in the water-soluble organic solvent is 1:0 to 0:1.
[0017] As for the bipyridine triazole type rare earth complex, if
Ln is europium, red light is emitted, and the main peak of an
emission spectrum is 621 nm; while terbium emits green light of
which the main peak is 545 nm; thulium emits blue light of which
the main peak is 470 nm; samarium emits pink light of which the
main peak is 640 nm; dysprosium emits yellow light of which the
main peak is 570 nm; and neodymium, erbium and ytterbium emit
infrared lights of which the main peaks are 1065 nm, 1509 nm and
978 nm respectively.
[0018] The invention is different from the prior art in the
following aspects: the bipyridine triazole type tridentate compound
is adopted as a single ligand, the coordination saturation is
simultaneously met, and a triazole group in the complex is taken as
negative ions to realize charge balance with the central rare earth
metal positive ions so as to realize electrical neutrality. As the
ligand is in tridentate coordination chelating with the rare earth
ions, the rare earth complexes have high thermal and electrical
stability and are suitable for being manufactured into devices by
an evaporation film-forming process; and in addition, by
modification of R.sub.1, R.sub.2 or R.sub.3, the rare earth
complexes which are easy to dissolve in an organic solvent and even
water are synthesized, and the rare earth complexes are also
suitable for being manufactured into devices by a solution
film-forming process.
[0019] The preparation method of the invention has the advantages
of high yield, good product purity, short reaction time and
simplicity in operation, and can greatly reduce cost.
BRIEF DESCRIPTION OF THE DRAWING
[0020] FIG. 1 is a mass spectrogram of
tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium (III).
[0021] FIG. 2 is a mass spectrogram of
tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium (III).
[0022] FIG. 3 is a mass spectrogram of
tri[3-bromo-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III).
[0023] FIG. 4 is a mass spectrogram of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]thulium
(III).
DETAILED DESCRIPTION OF THE INVENTION
[0024] The following embodiments are used for further describing
rather than limiting the invention.
Embodiment 1
Synthesis of
tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium (III)
(Compound 6)
[0025] The First Step: Preparation of N-oxo-2,2'-bipyridine
(Compound 2)
##STR00007##
[0026] Firstly, adding a compound (1) 2,2'-bipyridine (1000 and
acetic acid (500 mL) into a 2 L three-necked flask, uniformly
stirring, adding 30% H.sub.2O.sub.2 (70 mL), heating to
70-75.degree. C., and stifling to reacti for 3 h; cooling to room
temperature, adding 30% H.sub.2O.sub.2 (70 mL), continuously
heating to 60-110.degree. C. and reacting for 3 h; cooling to room
temperature, performing vacuum concentration to remove the acetic
acid so as to obtain a reddish brown viscous oily substance,
diluting with water (1000 mL), and regulating the pH to 8-9 by
using solid sodium carbonate; extracting an obtained solution by
using dichloromethane (1000 mL+500 mL.times.3), mixing organic
phases, and drying by using anhydrous sulfuric acid; and filtering,
increasing pressure for concentration on filtrate to obtain the
reddish brown oily substance, and directly putting the oily
substance into the next-step reaction without purification.
The Second Step: Preparation of 6-cyano-2,2'-bipyridine (Compound
3)
##STR00008##
[0027] Firstly, dissolving the oily substance (compound 2) obtained
in the previous step in 500 mL of dichloromethane, transferring
into the 2 L three-necked flask, and cooling to below 10.degree. C.
by an ice-water bath; dropping trimethylsilyl cyanide (TMSCN, 200
mL), and keeping the internal temperature below 25.degree. C.;
reacting by the ice-water bath for half an hour after the end of
dropping; dropping benzoyl chloride (60 mL), and keeping the
internal temperature below 25.degree. C.; reacting for 72 h at room
temperature after the end of dropping; cooling by an ice-salt bath
to lower the internal temperature to below 0.degree. C.; dropping a
saturated sodium hydrogen carbonate solution (1000 mL), keeping the
internal temperature below 10.degree. C. and stirring at room
temperature to react for 1 h after the end of dropping; then
loading a reaction system into a 5 L separatory funnel, and adding
the dichloromethane (2000 mL); washing an organic layer with water
(1000 mL.times.3), then washing with saturated brine (1000
mL.times.2), and drying with anhydrous sodium sulfate; filtering
out a drying agent; increasing pressure for concentration and
drying to obtain off-white semi-solids, and stirring and washing
for 4 h by using 500 mL of petroleum ether; filtering, and washing
a filter cake with the petroleum ether (100 mL); and performing
vacuum drying on obtained white powder at the temperature of
40.degree. C. for 8 h to obtain 70 g of white solid powder.
[0028] MS: [M+1]181.9, C11H7N3 M.W.=181, and 182 (M+H peak) and 204
(M+Na peak) are detected.
The Third Step: Preparation of
5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (Compounds 4 and 5)
##STR00009##
[0029] Adding the compound 3 (70 g), anhydrous ethanol (1000 mL)
and hydrazine hydrate (80%, 200 mL) into the 2 L three-necked
flask, stirring at room temperature to react for 8 h, and freezing
a reaction solution in a refrigerator for 16 h; filtering out
solids, washing with cold ethanol (100 mL), and draining; and
directly putting obtained needle-like light yellow crystals into
reaction without drying;
adding 80% formic acid (1000 mL) into the 2 L three-necked flask,
cooling to below 0.degree. C. by an ice-salt bath, then adding the
above needle-like crystals in batches, and keeping the internal
temperature below 5.degree. C.; reacting for 1 h under ice bath
conditions after the end of adding; performing heating and reflux
reaction for 2 h; cooling to room temperature; removing a solvent
by concentration; diluting obtained residues with water (1000 mL);
regulating the pH to about 9 by using sodium carbonate solids, and
extracting with ethyl acetate (1000 mL+500 mL.times.2); mixing
organic phases, and drying with anhydrous sodium sulfate; filtering
out the drying agent; increasing pressure for concentration and
drying to obtain off-white semi-solids, and stirring and washing
for 16 h by using petroleum ether:ethyl acetate=20:1 (V:V) (500
mL); filtering, draining, and washing a filter cake with the
petroleum ether (100 mL); and performing vacuum drying on the
filter cake at the temperature of 40.degree. C. for 8 h to obtain
40 g of white solid powder.
[0030] .sup.1HNMR (400 MHz, DMSO), ppm: 7.52 (1H, t), 8.01 (1H, t),
8.14 (2H, m), 8.33 (1H, s), 8.50 (1H, m), 8.74 (1H, d) and 8.84
(1H, d).
[0031] MS: [M+1]224.1, C12H9N5 M.W.=223, and 224 (M+H peak) and 246
(M+Na peak) are detected.
The Fourth Step: Preparation of
tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium (III)
(Compound 6) and Fluorescence Emission Spectrum Test
##STR00010##
[0032] Dissolving the compound 4 (6.7 g) and europium (III)
chloride hexahydrate (3.7 g) respectively in 50 mL of a mixed
solvent of anhydrous ethanol:water (V:V)=1:3 to prepare a solution
A and a solution B; adding 1.2 g of sodium hydroxide into the
solution A, and stirring to react for half an hour; then dropping
the solution B into a reaction flask of the solution A, and
stirring at room temperature to react for 8 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 3 h to obtain 9.5 g of light yellow green
powder.
[0033] MS: [M+1]820.0, EuC36H24N15 M.W.=818, and the peak height
ratio of M+H peak 818: M+H peak 820 is detected to be close to the
isotopic abundance ratio of Eu, namely 1:1. The mass spectrogram is
as shown in FIG. 1.
[0034] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium (III) are
592 m and 618 nm.
Embodiment 2
Synthesis of tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 7) and Fluorescence Emission Spectrum Test
##STR00011##
[0036] Dissolving the compound 4 (7.4 g) prepared in the previous
embodiment and terbium (III) chloride hexahydrate (3.7 g)
respectively in 50 mL of a mixed solvent of anhydrous ethanol:water
(V:V)=1:3 to prepare a solution C and a solution D; adding 1.2 g of
sodium hydroxide into the solution C, and stirring to react for
half an hour; then dropping the solution D into a reaction flask of
the solution C, and stirring at room temperature to react for 8 h;
and reducing pressure for evaporation after the end of reaction to
remove the solvent, performing vacuum drying on solids at the
temperature of 50.degree. C. for 3 h to obtain 9.3 g of yellow
powder.
[0037] MS: [M+1]825.9, TbC36H24N15 M.W.=825, and the peak height
ratio of M+H peak 826:827 is detected to be close to the isotopic
abundance ratio of Tb, namely 2:1. The mass spectrogram is as shown
in FIG. 2.
[0038] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium (III) are
490 nm, 544 nm, 586 nm and 623 nm.
Embodiment 3
Synthesis of
tri[5-(4,4'-dibromo-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 13) and Fluorescence Emission Spectrum Test
[0039] The First Step: Preparation of
N-oxo-4,4'-dibromo-2,2'-bipyridine (Compound 9)
##STR00012##
[0040] Firstly, adding 4,4'-dibromo-2,2'-bipyridine (compound 8,
200 g) and trichloromethane (800 mL) into a 2 L three-necked flask,
uniformly stirring, cooling to 0.degree. C., and slowly dropping a
trichloromethane (600 mL) solution of m-chloroperoxybenzoic acid
(180 g); continuously heating to room temperature, and stirring to
react for 3 h; continuously heating to 60.degree. C. and further
reacting for 3 h; cooling to room temperature, performing vacuum
concentration to remove the trichloromethane, diluting with water
(1000 mL), and regulating the pH to 8-9 by using solid sodium
carbonate; removing the raw material 4,4'-dibromo-2,2'-bipyridine
which does not completely react in a mixture by heating to
90-95.degree. C. for half an hour, cooling and performing suction
filtration; extracting obtained filtrate by using dichloromethane
(1000 mL+500 mL.times.3), mixing organic phases, and drying by
using anhydrous sulfuric acid; and filtering, concentrating and
recrystallizing by using petroleum ether to obtain 169 g of light
grey solids.
The Second Step: Preparation of
6-cyano-4,4'-dibromo-2,2'-bipyridine (Compound 10)
##STR00013##
[0041] Firstly, dissolving the product (compound 9, 73 g) obtained
in the previous step in 500 mL of dichloromethane, transferring
into the 2 L three-necked flask, and cooling to below 10.degree. C.
by an ice-water bath; dropping trimethylsilyl cyanide (TMSCN, 250
mL), and keeping the internal temperature below 15.degree. C.;
reacting by the ice-water bath for 1 h after the end of dropping;
dropping benzoyl chloride (50 mL), and keeping the internal
temperature below 15.degree. C.; reacting for 72 h at room
temperature after the end of dropping; cooling by an ice-salt bath
to lower the internal temperature to below 0.degree. C.; dropping a
saturated sodium hydrogen carbonate solution (1000 mL), keeping the
internal temperature below 10.degree. C. and stirring at room
temperature to react for 1 h after the end of dropping; then
loading a reaction system into a 5 L separatory funnel, and adding
the dichloromethane (2000 mL); washing an organic layer with water
(1000 mL.times.3), then washing with saturated brine (1000
mL.times.2), and drying with anhydrous sodium sulfate; filtering
out a drying agent; increasing pressure for concentration and
drying to obtain flesh pink solids; and recrystallizing by using
1000 mL of ethanol, filtering, washing, and performing vacuum
drying at the temperature of 50.degree. C. for 8 h to obtain 56 g
of grey solids.
[0042] MS: [M-1]337.9, C11H5Br2N3 M.W.=339, and the peak height
ratio of M-H peak 336:338:340 is detected to be close to 1:2:1,
which is in line with the number of atoms and the isotopic
abundance ratio of Br.
The Third Step: Preparation of
5-(4,4'-dibromo-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (Compounds
11 and 12)
##STR00014##
[0043] Adding the compound 10 (50 g), anhydrous ethanol (500 mL)
and hydrazine hydrate (80%, 50 mL) into the 2 L three-necked flask,
stirring at room temperature to react for 8 h, and freezing a
reaction solution in a refrigerator for 16 h; filtering out the
solids, washing with cold ethanol (60 mL), and draining; and
directly putting obtained yellow solids into reaction without
drying;
adding 80% of formic acid (1000 mL) into the 2 L three-necked
flask, cooling to below 0.degree. C. by the ice-salt bath, then
adding the above yellow crystals in batches, and keeping the
internal temperature below 5.degree. C.; reacting for 1 h under ice
bath conditions after the end of adding and reacting at room
temperature for 1 h; then performing heating and reflux reaction
for 4 h; cooling to room temperature; removing a solvent by
concentration; diluting obtained residues with water (1000 mL);
regulating the pH to about 9 by using sodium carbonate solids, and
extracting with ethyl acetate (1000 mL+500 mL.times.2); mixing
organic phases, and drying with anhydrous sodium sulfate;
performing decompression concentration and drying on filtrate to
obtain light green solids, and stirring and washing for 16 h by
using petroleum ether:ethyl acetate=20:1 (V:V) (500 mL); filtering,
draining, and washing a filter cake with the petroleum ether (100
mL); and performing vacuum drying on the filter cake at the
temperature of 40.degree. C. for 8 h to obtain 24 g of light green
solid powder.
[0044] MS: C12H7Br2N5 M.W.=381, and the height ratio of 378:380:382
(M-H peak) is detected to be 1:2:1, which is in line with the
number of atoms and the isotopic abundance ratio of Br.
The Fourth Step: Preparation of
tri[5-(4,4'-dibromo-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 13) and Fluorescence Emission Spectrum Test
##STR00015##
[0045] Dissolving the compound 11 (11.4 g) and terbium (III)
chloride hexahydrate (3.70 respectively in 50 mL of a mixed solvent
of ethylene glycol:water (V:V)=1:3 to prepare a solution E and a
solution F; adding 1.2 g of sodium hydroxide into the solution E,
and stirring to react for half an hour; then dropping the solution
F into a reaction flask of the solution E, and stirring at room
temperature to react for 16 h; and reducing pressure for
evaporation after the end of reaction to remove the solvent,
performing vacuum drying on the solids at the temperature of
50.degree. C. for 3 h to obtain 10.5 g of yellow green powder.
[0046] MS: [M+1]1299.4, TbC36H18Br6N15 M.W.=1298, and the peak
height ratio of M+H peak 1297:1299:1301 is detected to be in line
with the isotopic abundance ratio of complex molecules.
[0047] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[5-(4,4'-dibromo-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) are 495 nm, 546 nm, 585 nm and 627 nm.
Embodiment 4
Synthesis of
tri[5-(4,4'-dimethyl-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) (Compound 19) and Fluorescence Emission Spectrum Test
[0048] The First Step: Preparation of
N-oxo-4,4'-dimethyl-2,2'-bipyridine (Compound 15)
##STR00016##
[0049] Referring to the synthesis method of the compound 9, light
yellow crystals, namely N-oxo-4,4'-dimethyl-2,2'-bipyridine
(compound 15, 89 g) can be prepared from
4,4'-dimethyl-2,2'-bipyridine (compound 14, 100 g).
[0050] .sup.1H NMR (CDCl.sub.3 ppm) .delta.2.36 (3H, s), 2.41 (3H,
s), 6.98-7.20 (2H, m), 7.96 (1H, m), 8.22 (1H, d), 8.58 (1H, d),
8.78 (1H, m).
[0051] Elementary analysis Anal. Calcd. For C12H12N2O: C, 71.98; H,
6.04; N, 13.99. Found: C, 71.88; H, 6.01; N, 14.03.
The Second Step: Preparation of
6-cyano-4,4'-dimethyl-2,2'-bipyridine (Compound 16)
##STR00017##
[0052] Referring to the synthesis method of the compound 10, yellow
solids, namely 6-cyano-4,4'-dimethyl-2,2'-bipyridine (compound 16,
66 g) can be prepared from N-oxo-4,4'-dimethyl-2,2'-bipyridine
(compound 15, 80 g).
The Third Step: Preparation of
5-(4,4'-dimethyl-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (Compounds
17 and 18)
##STR00018##
[0053] Referring to the synthesis method of the compound 11, earth
yellow solid powder
5-dimethyl-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (compounds 17
and 18, 31 g) can be prepared from the compound 16 (50 g).
[0054] MS: C14H13N5 M.W.=251, and 252 (1\4+H peak) and 274 (M+Na
peak) are detected.
The Fourth Step: Preparation of
tri[5-(4,4'-dimethyl-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) (Compound 19) and Fluorescence Emission Spectrum Test
##STR00019##
[0055] Dissolving the compound 17 (7.6 g) and europium (III)
chloride hexahydrate (3.9 g) respectively in 50 mL of a mixed
solvent of ethanol:water (V:V)=1:2 to prepare a solution G and a
solution H; adding 1.2 g of sodium hydroxide into the solution G,
and stirring to react for half an hour; then dropping the solution
H into a reaction flask of the solution G, and stirring at room
temperature to react for 20 h; and reducing pressure for
evaporation after the end of reaction to remove the solvent,
performing vacuum drying on the solids at the temperature of
50.degree. C. for 3 h to obtain 9.2 g of yellow powder.
[0056] MS: [M+1]904.3 EuC42H36N15 M.W.=902, and the peak height
ratio of M+H peak 902:904 is detected to be close to the isotopic
abundance ratio of Eu, namely 1:1.
[0057] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[5-(4,4'-dibromo-2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) are 595 nm and 617 nm.
Embodiment 5
Synthesis of
tri[3-bromo-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 21) and Fluorescence Emission Spectrum Test
[0058] 5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (compound 4, 20
g) is prepared by with reference to embodiment 1 to be used as raw
material.
The First Step: Preparation of
3-bromo-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (Compound
20)
##STR00020##
[0059] Adding 5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (compound
4, 20 g) and water (300 mL) into a 1 L three-necked flask,
uniformly stirring and slowly dropping 10M of NaOH solution to
gradually dissolve the compound 4; regulating the pH=12, and
enabling the solution to become clear; dropping 13.6 mL of liquid
bromine (43.6 g) to react, simultaneously dropping 10M of NaOH
solution to keep the pH of a reaction solution=12, and stirring to
react for 3 h; regulating the pH to 3-4 by using 6M of hydrochloric
acid after the end of reaction to obtain a crude product; and
filtering, recrystallizing by using ethanol, and performing vacuum
drying to obtain 14.2 g of yellow solids, namely
3-bromo-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (compound
20).
[0060] MS: C12H8BrN5 M.W.=302, and the peak height ratio of M+H
peak 302:304 is detected to be close to the isotopic abundance
ratio of Br, namely 1:1.
The Second Step: Preparation of
tri[3-bromo-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 21) and Fluorescence Emission Spectrum Test
##STR00021##
[0061] Dissolving the compound 20 (9.1a) and terbium (III) chloride
hexahydrate (3.7 g) respectively in 50 mL of a mixed solvent of
1,3-propylene glycol:water (V:V)=1:3 to prepare a solution I and a
solution J; adding 1.2 g of sodium hydroxide into the solution I,
and stirring to react for half an hour; then dropping the solution
J into a reaction flask of the solution I, and stirring at room
temperature to react for 24 h; and reducing pressure for
evaporation after the end of reaction to remove the solvent,
performing vacuum drying on the solids at the temperature of
50.degree. C. for 3 h to obtain 10.1 g of yellow powder.
[0062] Ms: [M+1]1063.9, TbC36H21Br3N15 M.W.=1062 and the peak
height ratio of M+H peak 1062:1064 is detected to be in line with
the isotopic abundance ratio of complex molecules. The mass
spectrogram is as shown in FIG. 3.
[0063] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[3-bromo-5-(2,2-bipyridine-6-yl)-1,2,4-1H-triazole]terbium (III)
are 493 nm, 545 nm, 585 nm and 626 nm.
Embodiment 6
Synthesis of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) (Compound 24) and Fluorescence Emission Spectrum Test
[0064] Referring to the method of embodiment 1 or embodiment
3,6-cyano-2,2'-bipyridine (compound 3, 70 g) can be prepared as
reaction raw material
The First Step: Preparation of
3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole
(Compounds 22 and 23)
##STR00022##
[0065] Adding the compound 3 (70 g), ethanol (500 mL), water (200
mL) and hydrazine hydrate (80%, 200 mL) into the 2 L three-necked
flask, stirring at room temperature to react for 8 h, and freezing
a reaction solution in a refrigerator for 16 h; filtering out
solids, washing with cold ethanol (100 mL), and draining; and
directly putting obtained needle-like light yellow crystals into
reaction without drying;
adding trifluoroacetic acid (400 mL) into the 1 L three-necked
flask, cooling to below 0.degree. C. by the ice-salt bath, then
adding the above solids in batches, and keeping the internal
temperature below 5.degree. C.; reacting for 2 h under ice bath
conditions after the end of adding; then performing heating and
reflux reaction for 4 h; cooling to room temperature; removing a
solvent by concentration; diluting obtained residues with water
(2000 mL); regulating the pH to about 9 by using sodium carbonate
solids, and extracting with ethyl acetate (1000 mL+400 mL.times.2);
mixing organic phases, drying with anhydrous sodium sulfate and
decoloring by using activated carbon; filtering out a drying agent,
performing decompression concentration and drying to obtain white
solids, and stirring and washing for 16 h by using petroleum
ether:ethyl acetate=1:1 (V:V) (500 mL); filtering, draining, and
washing a filter cake with the petroleum ether (200 mL); and
performing vacuum drying on the filter cake at the temperature of
40.degree. C. for 8 h to obtain 54 g of white solid powder.
[0066] .sup.1HNMR (300 MHz, DMSO), ppm: 7.55 (1H, t), 8.09 (1H, t),
8.19 (2H, d), 8.58 (1H, t), 8.75 (1H, d) and 8.93 (1H, d).
[0067] MS: C13H8F3N5 M.W.=291, and 292 (M+H peak) and 314 (M+Na
peak) are detected.
The Second Step: Preparation of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) (Compound 24) and Fluorescence Emission Spectrum Test
##STR00023##
[0068] Dissolving the compound 22 (8.7 g) and europium (III)
chloride hexahydrate (3.9 g) respectively in 50 mL of a mixed
solvent of ethylene glycol:water (V:V)=1:1 to prepare a solution K
and a solution L; adding 1.2 g of sodium hydroxide into the
solution K, and stirring to react for half an hour; then dropping
the solution L into a reaction flask of the solution K, and
stirring at room temperature to react for 16 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 3 h to obtain 9.5 g of light yellow
powder.
[0069] MS: [M+1]1024.3, EuC39H.sub.21F.sub.9N.sub.15 M.W.=1022, and
the peak height ratio of M+H peak 1022:1024 is detected to be close
to the isotopic abundance ratio of Eu, namely 1:1.
[0070] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) are 593 nm and 618 nm.
Embodiment 7
Synthesis of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]neodymiu-
m (III) (Compound 25) and Fluorescence Emission Spectrum Test
##STR00024##
[0072] Dissolving the compound 22 (8.7 g) prepared in embodiment 6
and neodymium nitrate (3.3 g) respectively in 50 mL of a mixed
solvent of ethanol:water (V:V)=1:3 to prepare a solution M and a
solution N; adding 1.2 g of sodium hydroxide into the solution M,
and stirring to react for half an hour; then dropping the solution
N into a reaction flask of the solution M, and stirring at room
temperature to react for 16 h; and reducing pressure for
evaporation after the end of reaction to remove the solvent,
performing vacuum drying on the solids at the temperature of
50.degree. C. for 3 h to obtain 9.8 g of yellow powder.
[0073] MS: [M+1]1015.4, NdC39H21F9N15 M.W.=1014 and M+H peak 1015
and M+Na peak 1037 are detected.
[0074] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelength of the
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]neodymiu-
m (III) is 1062 nm.
Embodiment 8
Synthesis of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]samarium
(III) (Compound 26) and Fluorescence Emission Spectrum Test
##STR00025##
[0076] Dissolving the compound 22 (8.7 g) prepared in embodiment 6
and samarium (III) chloride hexahydrate (3.6 g) respectively in 50
mL of a mixed solvent of ethylene glycol:water (V:V)=1:2 to prepare
a solution O and a solution P; adding 1.2 g of sodium hydroxide
into the solution O, and stirring to react for half an hour; then
dropping the solution P into a reaction flask of the solution O,
and stirring to react at room temperature for 48 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 4 h to obtain 10.5 g of light yellow
powder.
[0077] MS: [M+1]1020.3, SmC39H21F9N15 M.W.=1020, and the peak
height ratio of M+H peak 1020:1023 is detected to be close to the
isotopic abundance ratio of Sm.
[0078] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelength of the
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]samarium
(III) is 642 nm.
Embodiment 9
Synthesis of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 27) and Fluorescence Emission Spectrum Test
##STR00026##
[0080] Dissolving the compound 22 (8.7 g) prepared in embodiment 6
and terbium (III) chloride hexahydrate (3.7 g) in 50 mL of mixed
solvent of 1,3-propylene glycol:water (V:V)=1:3 to prepare a
solution Q and a solution R; adding 1.2 g of sodium hydroxide into
the solution Q, and stirring to react for half an hour; then
dropping the solution R into a reaction flask of the solution Q,
and stirring at room temperature to react for 16 h; and evaporation
after the end of reaction to remove the solvent, performing vacuum
drying on the solids at the temperature of 50.degree. C. for 3 h to
obtain 9.6 g of yellow green powder.
[0081] MS: [M+1]1030.2, TbC39H21F9N15 M.W.=1029, and the peak
height ratio of M+H peak 1030:1031 is detected to be close to the
isotopic abundance ratio of Tb, namely 2:1.
[0082] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) are 492 nm, 545 nm, 583 nm and 621 nm.
Embodiment 10
Synthesis of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]dysprosi-
um (III) (Compound 28) and Fluorescence Emission Spectrum Test
##STR00027##
[0084] Dissolving the compound 22 (8.7 g) prepared in embodiment 6
and dysprosium perchlorate (4.6 g) respectively in 50 mL of a mixed
solvent of 1,3-propylene glycol:water (V:V)=1:1 to prepare a
solution S and a solution T; adding 1.2 g of sodium hydroxide into
the solution S, and stirring to react for half an hour; then
dropping the solution T into a reaction flask of the solution S,
and stirring at room temperature to react for 24 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 4 h to obtain 10.1 g of earth yellow
powder.
[0085] MS: [M+1]1034.3, DyC39H21F9N15 M.W.=1033, and the peak
height ratio of 1\4+H peak 1033:1034:1035 is detected to be close
to the isotopic abundance ratio of Dy, namely 1:1:1.
[0086] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelength of the
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]dysprosi-
um (III) is 573 nm.
Embodiment 11
Synthesis of
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]thulium
(III) (Compound 29) and Fluorescence Emission Spectrum Test
##STR00028##
[0088] Dissolving the compound 22 (8.7 g) prepared in embodiment 6
and thulium nitrate (3.5 g) respectively in 50 mL of a mixed
solvent of 1,2-propylene glycol:water (V:V)=1:3 to prepare a
solution U and a solution V; adding 1.2 g of sodium hydroxide into
the solution U, and stirring to react for half an hour; then
dropping the solution V into a reaction flask of the solution U,
and stirring at room temperature to react for 48 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 4 h to obtain 9.3 g of yellow powder.
[0089] MS: [M+1]1040.3, TmC39H21F9N15 M.W.=1039, and M+H peak 1040
and M+Na peak 1062 are detected. The mass spectrogram is as shown
in FIG. 4.
[0090] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelength of the
tri[3-trifluoromethyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]thulium
(III) is 467 nm.
Embodiment 12
Synthesis of
tri[3-phenyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) (Compound 32) and Fluorescence Emission Spectrum Test
[0091] Referring to the method of embodiment 1 or embodiment
3,6-cyano-2,2'-bipyridine (compound 3, 70 g) can be prepared as
reaction raw material
The First Step: Preparation of
3-phenyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole (Compounds 30
and 31)
##STR00029##
[0092] Adding the compound 3 (70 g), ethanol (500 mL), water (200
mL) and hydrazine hydrate (80%, 200 mL) into the 2 L three-necked
flask, stirring at room temperature to react for 8 h, and freezing
a reaction solution in a refrigerator for 16 h; filtering out
solids, washing with cold ethanol (100 mL), and draining; directly
putting obtained needle-like light yellow crystals into reaction
without drying; filtering out the solids, washing with cold ethanol
(100 mL) and draining; directly putting obtained needle-like light
yellow crystals into the reaction without drying;
adding the above solids, toluene (500 mL) and triethylamine (60 g)
into the 2 L three-necked flask, cooling to below 0.degree. C. by
the ice-salt bath, then dropping benzoyl chloride (72 g), and
keeping the internal temperature below 5.degree. C.; reacting for 2
h under ice bath conditions after the end of adding; turning to
room temperature to react for 4 h; adding petroleum ether (1500
mL), stirring, and further adding 1 L of water, and stirring for
half an hour; then filtering and draining to obtain white solids;
transferring the solids into the 2 L three-necked flask, adding the
toluene (1000 mL) and p-toluenesulfonic acid monohydrate crystals
(8.7 g), and performing heating, reflux and water separation
reaction for 24 h; removing a solvent by concentration, adding
water (1000 mL), and then regulating the pH to 8-9 by using sodium
carbonate solids; extracting with ethyl acetate (1000 mL+400
mL.times.2); mixing organic phases, drying with anhydrous sodium
sulfate and decoloring by using activated carbon; filtering out a
drying agent, increasing pressure for concentration and drying to
obtain white solids, and recrystallizing by using petroleum
ether:ethyl acetate=3:1 (V:V) (800 mL); and filtering, draining,
and performing vacuum drying on a filter cake at the temperature of
40.degree. C. for 8 h to obtain 68 g of white solid powder.
[0093] .sup.1HNMR (300 MHz, DMSO), ppm: 7.56 (3H, m), 7.69, t),
8.08 (1H, t), 8.22-8.14 (4H, m), 8.62 (1H, t), 8.75 (1H, d), 8.93
(1H, d) and 14.9 (1H, brs).
[0094] MS: C18H13N5 M.W.=299, and 300 (1\4+H peak) and 322 (M+Na
peak) are detected.
The Second Step: Preparation of
tri[3-phenyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) (Compound 32) and Fluorescence Emission Spectrum Test
##STR00030##
[0095] Dissolving the compound 30 (9.0 g) and europium (III)
chloride hexahydrate (3.7 g) respectively in 50 mL of a mixed
solvent of 2-methoxyethanol:water (V:V)=1:3 to prepare a solution W
and a solution X; adding 1.2 g of sodium hydroxide into the
solution W, and stirring to react for half an hour; then dropping
the solution X into a reaction flask of the solution W, and
stirring at room temperature to react for 16 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 3 h to obtain 9.8 g of light yellow
powder.
[0096] MS: [M+1]1048.4, EuC48H36N15 M.W.=1046 and the peak height
ratio of M+H peak 1046:1048 is detected to be close to the isotopic
abundance ratio of Eu, namely 1:1.
[0097] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[3-phenyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]europium
(III) are 594 nm and 619 nm.
Embodiment 13
Synthesis of
tri[3-phenyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) (Compound 33) and Fluorescence Emission Spectrum Test
##STR00031##
[0099] Dissolving the compound 30 (9.0 g) prepared in embodiment 12
and terbium (III) chloride hexahydrate (3.7 g) respectively in 50
mL of a mixed solvent of 2-eyhoxyethanol:water (V:V)=1:3 to prepare
a solution Y and a solution Z; adding 1.2 g of sodium hydroxide
into the Y solution, and stirring to react for half an hour; then
dropping the Z solution into a reaction flask of the Y solution,
and stirring at room temperature to react for 16 h; and reducing
pressure for evaporation after the end of reaction to remove the
solvent, performing vacuum drying on the solids at the temperature
of 50.degree. C. for 3 h to obtain 9.9 g of yellow powder.
[0100] MS: [M+1]1054.2, TbC48H36N15 M.W.=1053, and the peak height
ratio of M+H peak 1054:1055 is detected to be close to the isotopic
abundance ratio of Tb, namely 2:1.
[0101] Through fluorescence emission spectrum test, we can know
that the fluorescence emission wavelengths of the
tri[3-phenyl-5-(2,2'-bipyridine-6-yl)-1,2,4-1H-triazole]terbium
(III) are 488 nm, 545 nm, 590 nm and 623 nm.
* * * * *