| Patent | Date |
|---|
Treatment Of Cancer With Tor Kinase Inhibitors
App 20220273650 - XU; Shuichan ; et al. | 2022-09-01 |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
Grant 11,325,890 - Delgado , et al. May 10, 2 | 2022-05-10 |
Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Grant 11,292,796 - Elsner , et al. April 5, 2 | 2022-04-05 |
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide, compositions thereof and methods of their use
Grant 11,241,430 - Beauchamps , et al. February 8, 2 | 2022-02-08 |
Treatment of cancer with TOR kinase inhibitors
Grant 11,166,950 - Xu , et al. November 9, 2 | 2021-11-09 |
Isotopologues Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20210221772 - MAN; Hon-Wah ; et al. | 2021-07-22 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20210128565 - Alexander; Matthew ; et al. | 2021-05-06 |
Substituted Diaminocarboxamide And Diaminocarbonitrile Pyrimidines, Compositions Thereof, And Methods Of Treatment Therewith
App 20210114992 - Delgado; Mercedes ; et al. | 2021-04-22 |
Isotopologues of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide
Grant 10,975,039 - Man , et al. April 13, 2 | 2021-04-13 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 10,940,152 - Alexander , et al. March 9, 2 | 2021-03-09 |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
Grant 10,919,865 - Delgado , et al. February 16, 2 | 2021-02-16 |
Isotopologues Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20200270215 - MAN; Hon-Wah ; et al. | 2020-08-27 |
PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
App 20200262840 - ELSNER; Jan ; et al. | 2020-08-20 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20200237768 - Alexander; Matthew ; et al. | 2020-07-30 |
Isotopologues of 2-(tert butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5- -carboxamide
Grant 10,689,351 - Man , et al. | 2020-06-23 |
Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Grant 10,683,298 - Elsner , et al. | 2020-06-16 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 10,646,493 - Alexander , et al. | 2020-05-12 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20200113896 - LOPEZ-GIRONA; ANTONIA ; et al. | 2020-04-16 |
Formulations of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide
Grant 10,590,089 - Boersen , et al. | 2020-03-17 |
Solid Forms Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide, Compositions The
App 20200078359 - Beauchamps; Marie Georges ; et al. | 2020-03-12 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 10,576,085 - Boylan , et al. | 2020-03-03 |
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide, compositions thereof and methods of their use
Grant 10,517,873 - Beauchamps , et al. Dec | 2019-12-31 |
Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-- trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use
Grant 10,513,519 - Chen , et al. Dec | 2019-12-24 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20190336507 - Alexander; Matthew ; et al. | 2019-11-07 |
Isotopologues Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20190315697 - MAN; Hon-Wah ; et al. | 2019-10-17 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 10,398,700 - Alexander , et al. Sep | 2019-09-03 |
Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
Grant 10,391,092 - Raymon , et al. A | 2019-08-27 |
Substituted Diaminocarboxamide And Diaminocarbonitrile Pyrimidines, Compositions Thereof, And Methods Of Treatment Therewith
App 20190194144 - Delgado; Mercedes ; et al. | 2019-06-27 |
Solid Forms Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide, Compositions The
App 20190167678 - Beauchamps; Marie Georges ; et al. | 2019-06-06 |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
Grant 10,266,500 - Bennett , et al. | 2019-04-23 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20190091230 - Alexander; Matthew ; et al. | 2019-03-28 |
PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
App 20190077806 - ELSNER; Jan ; et al. | 2019-03-14 |
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide, compositions thereof and methods of their use
Grant 10,226,461 - Man , et al. | 2019-03-12 |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
Grant 10,197,579 - Horan , et al. Fe | 2019-02-05 |
Formulations Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20190031619 - BOERSEN; Nathan Andrew ; et al. | 2019-01-31 |
Treatment of cancer with dihydropyrazino-pyrazines
Grant 10,183,019 - Raymon , et al. Ja | 2019-01-22 |
Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Grant 10,167,290 - Elsner , et al. J | 2019-01-01 |
Solid Forms Of (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahydro-2h-pyran-4-yl)amino)-8-((2,4,6-- Trichlorophenyl)amino)-9h-purin-9-yl)-1-methylcyclohexane-1-carboxamide And Methods Of Their Use
App 20180362529 - Chen; Zheng ; et al. | 2018-12-20 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 10,149,849 - Alexander , et al. Dec | 2018-12-11 |
Formulations of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4methylcyclohexylamino)-pyrim- idine-5-carboxamide
Grant 10,131,639 - Boersen , et al. November 20, 2 | 2018-11-20 |
Substituted Diaminocarboxamide And Diaminocarbonitrile Pyrimidines, Compositions Thereof, And Methods Of Treatment Therewith
App 20180305322 - Bennett; Brydon L. ; et al. | 2018-10-25 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20180235960 - XU; Shuichan ; et al. | 2018-08-23 |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- azino[2,3-b]pyrazin-2(1H)-one
Grant 10,052,322 - Menon , et al. August 21, 2 | 2018-08-21 |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(trans)-4-methoxycyclohexyl)-3- ,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use
Grant 10,052,323 - Klopfer August 21, 2 | 2018-08-21 |
Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-- trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use
Grant 10,047,090 - Chen , et al. August 14, 2 | 2018-08-14 |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
Grant 10,040,770 - Delgado , et al. August 7, 2 | 2018-08-07 |
Pharmaceutical Compositions Of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, A Solid Form Thereof And Methods Of Their Use
App 20180200252 - KLOPFER; Kevin | 2018-07-19 |
Methods For Treating Cancer Using Dihydropyrazino-pyrazine Compound Combination Therapy
App 20180185361 - RAYMON; HEATHER ; et al. | 2018-07-05 |
Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
Grant 10,004,735 - Fultz , et al. June 26, 2 | 2018-06-26 |
Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- azino[2,3-b]pyrazin-2(1H)-one as TOR kinase inhibitors
Grant 9,981,971 - Boersen May 29, 2 | 2018-05-29 |
Treatment of cancer with dihydropyrazino-pyrazines
Grant 9,980,963 - Raymon , et al. May 29, 2 | 2018-05-29 |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino[2,3- B]pyrazin-2(1H)-one, a solid form there of and methods of their use
Grant 9,974,786 - Beauchamps , et al. May 22, 2 | 2018-05-22 |
Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-YL)-3,4-dihydropyr- azino [2,3-b]pyrazin-2(1H)-one as tor kinase inhibitors
Grant 9,975,898 - Eckert May 22, 2 | 2018-05-22 |
Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
Grant 9,937,169 - Raymon , et al. April 10, 2 | 2018-04-10 |
Treatment of cancer with TOR kinase inhibitors
Grant 9,937,170 - Xu , et al. April 10, 2 | 2018-04-10 |
Pharmaceutical Compositions Of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, A Solid Form Thereof And Methods Of Their Use
App 20180071287 - BEAUCHAMPS; Marie Georges ; et al. | 2018-03-15 |
PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE
App 20180042924 - Menon; Anil ; et al. | 2018-02-15 |
Solid Forms Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide, Compositions Thereof And Methods Of Their Use
App 20180028534 - Man; Hon-Wah ; et al. | 2018-02-01 |
Isotopologues Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20180022710 - MAN; Hon-Wah ; et al. | 2018-01-25 |
Formulations Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20180009765 - BOERSEN; Nathan Andrew ; et al. | 2018-01-11 |
PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
App 20170342080 - ELSNER; Jan ; et al. | 2017-11-30 |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- azino[2,3-b]pyrazin-2(1H)-one
Grant 9,827,243 - Kreilein , et al. November 28, 2 | 2017-11-28 |
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide, compositions thereof and methods of their use
Grant 9,814,713 - Man , et al. November 14, 2 | 2017-11-14 |
METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY COMPRISING ADMINISTERING SUBSTITUTED PYRAZINO[2,3-b]PYRAZINES
App 20170312278 - FULTZ; Kimberly Elizabeth ; et al. | 2017-11-02 |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-B]pyrazin-2(1H)-one, a solid form thereof and methods of their use
Grant 9,795,603 - Beauchamps , et al. October 24, 2 | 2017-10-24 |
Formulations of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-Methylcyclohexylamino)-pyri- midine-5-carboxamide
Grant 9,796,685 - Boersen , et al. October 24, 2 | 2017-10-24 |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
Grant 9,795,607 - Calabrese , et al. October 24, 2 | 2017-10-24 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20170296546 - Alexander; Matthew ; et al. | 2017-10-19 |
Methods for treating cancer using TOR kinase inhibitor combination therapy
Grant 9,782,427 - Raymon October 10, 2 | 2017-10-10 |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
Grant 9,783,505 - Papa , et al. October 10, 2 | 2017-10-10 |
Solid Forms Of (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahydro-2h-pyran-4-yl)amino)-8-((2,4,6-- Trichlorophenyl)amino)-9h-purin-9-yl)-1-methylcyclohexane-1-carboxamide And Methods Of Their Use
App 20170283418 - Chen; Zheng ; et al. | 2017-10-05 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20170281633 - Boylan; John F. ; et al. | 2017-10-05 |
Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Grant 9,771,371 - Elsner , et al. September 26, 2 | 2017-09-26 |
Substituted Diaminocarboxamide And Diaminocarbonitrile Pyrimidines, Compositions Thereof, And Methods Of Treatment Therewith
App 20170267647 - Delgado; Mercedes ; et al. | 2017-09-21 |
Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
Grant 9,737,535 - Fultz , et al. August 22, 2 | 2017-08-22 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 9,737,541 - Alexander , et al. August 22, 2 | 2017-08-22 |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Grant 9,725,450 - Clareen , et al. August 8, 2 | 2017-08-08 |
Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
Grant 9,718,824 - Klopfer August 1, 2 | 2017-08-01 |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
Grant 9,701,643 - Bennett , et al. July 11, 2 | 2017-07-11 |
Pharmaceutical Compositions Of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, A Solid Form Thereof And Methods Of Their Use
App 20170182042 - BEAUCHAMPS; Marie Georges ; et al. | 2017-06-29 |
Treatment Of Cancer With Dihydropyrazino-pyrazines
App 20170182044 - RAYMON; HEATHER ; et al. | 2017-06-29 |
Methods Of Treating A Cancer Using Substituted Pyrrolopyrimidine Compounds, Compositions Thereof
App 20170173024 - ZHU; Dan ; et al. | 2017-06-22 |
Treatment of cancer with dihydropyrazino-pyrazines
Grant 9,630,966 - Raymon , et al. April 25, 2 | 2017-04-25 |
Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
Grant 9,623,028 - Zhu , et al. April 18, 2 | 2017-04-18 |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-YL)pyridin-3-YL)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-B]pyrazin-2(1H)-one, a solid form thereof and methods of their use
Grant 9,604,939 - Beauchamps , et al. March 28, 2 | 2017-03-28 |
Treatment Of Cancer With Dihydropyrazino-pyrazines
App 20170065583 - RAYMON; HEATHER ; et al. | 2017-03-09 |
SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
App 20170044170 - ECKERT; Jeffrey | 2017-02-16 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20170042902 - Alexander; Matthew ; et al. | 2017-02-16 |
Methods For Measurement Of Inhibition Of C-jun N-terminal Kinase In Skin
App 20170045531 - HORAN; Gerald Scott Barden ; et al. | 2017-02-16 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20170027932 - XU; Shuichan ; et al. | 2017-02-02 |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
Grant 9,556,126 - Papa , et al. January 31, 2 | 2017-01-31 |
Identification of LKB1 mutation as a predictive biomarker for sensitivity to TOR kinase inhibitors
Grant 9,555,033 - Chopra , et al. January 31, 2 | 2017-01-31 |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for tor kinase inhibitory activity
Grant 9,557,338 - Xu , et al. January 31, 2 | 2017-01-31 |
Substituted Diaminopyrimidyl Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20160354374 - Papa; Patrick ; et al. | 2016-12-08 |
Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- azino[2,3-b]pyrazin-2(1H)-one and a coformer
Grant 9,512,129 - Eckert December 6, 2 | 2016-12-06 |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Grant 9,512,124 - Alexander , et al. December 6, 2 | 2016-12-06 |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
Grant 9,513,297 - Horan , et al. December 6, 2 | 2016-12-06 |
Treatment of cancer with dihydropyrazino-pyrazines
Grant 9,505,764 - Raymon , et al. November 29, 2 | 2016-11-29 |
Treatment of cancer with TOR kinase inhibitors
Grant 9,493,466 - Xu , et al. November 15, 2 | 2016-11-15 |
SOLID FORMS OF 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
App 20160318940 - BOERSEN; Nathan | 2016-11-03 |
Methods for treating cancer using TOR kinase inhibitor combination therapy
Grant 9,474,757 - Hege , et al. October 25, 2 | 2016-10-25 |
Solid Forms Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide, Compositions Thereof And Methods Of Their Use
App 20160256459 - Man; Hon-Wah ; et al. | 2016-09-08 |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]p- yrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
Grant 9,434,735 - Chen , et al. September 6, 2 | 2016-09-06 |
PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE
App 20160250210 - Menon; Anil ; et al. | 2016-09-01 |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
Grant 9,428,509 - Calabrese , et al. August 30, 2 | 2016-08-30 |
Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- azino[2,3-b]pyrazin-2(1H)-one, as TOR kinase inhibitors
Grant 9,416,134 - Eckert August 16, 2 | 2016-08-16 |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use
Grant 9,403,829 - Connolly , et al. August 2, 2 | 2016-08-02 |
Method for treating advanced non-small cell lung cancer (NSCLC) by administering a combination of a TOR kinase inhibitor and azacitidine or erlotinib
Grant 9,375,443 - Xu , et al. June 28, 2 | 2016-06-28 |
Formulations Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide
App 20160168105 - BOERSEN; Nathan Andrew ; et al. | 2016-06-16 |
Methods For Measurement Of Inhibition Of C-jun N-terminal Kinase In Skin
App 20160169908 - HORAN; Gerald Scott Barden ; et al. | 2016-06-16 |
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyri- midine-5-carboxamide, compositions thereof and methods of their use
Grant 9,365,524 - Man , et al. June 14, 2 | 2016-06-14 |
Methods for treating cancer using TOR kinase inhibitor combination therapy
Grant 9,358,232 - Hege , et al. June 7, 2 | 2016-06-07 |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- azino[2,3-b] pyrazin-2(1H)-one
Grant 9,359,364 - Menon , et al. June 7, 2 | 2016-06-07 |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
Grant 9,346,812 - Calabrese , et al. May 24, 2 | 2016-05-24 |
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20160096841 - Alexander; Matthew ; et al. | 2016-04-07 |
Haloaryl Substituted Aminopurines, Compositions Thereof,and Methods Of Treatment Therewith
App 20160039822 - CLAREEN; STEVEN ; et al. | 2016-02-11 |
PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
App 20160024101 - ELSNER; Jan ; et al. | 2016-01-28 |
Methods Of Treating A Cancer Using Substituted Pyrrolopyrimidine Compounds, Compositions Thereof
App 20160008365 - ZHU; Dan ; et al. | 2016-01-14 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20160008356 - HEGE; Kristen Mae | 2016-01-14 |
Amorphous Form Of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]p- Yrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, Compositions Thereof And Methods Of Their Use
App 20160009722 - CHEN; Ming J. ; et al. | 2016-01-14 |
Inhibition Of Phosphorylation Of Pras40, Gsk3-beta Or P70s6k1 As A Marker For Tor Kinase Inhibitory Activity
App 20150362505 - Xu; Weiming ; et al. | 2015-12-17 |
Pharmaceutical formulations of a substituted diaminopurine
Grant 9,198,866 - Bhat , et al. December 1, 2 | 2015-12-01 |
Substituted Diaminocarboxamide And Diaminocarbonitrile Pyrimidines, Compositions Thereof, And Methods Of Treatment Therewith
App 20150336901 - Bennett; Brydon L. ; et al. | 2015-11-26 |
Halogen substituted pyrazines as intermediates of mTOR kinase inhibitors
Grant 9,193,692 - Perrin-Ninkovic , et al. November 24, 2 | 2015-11-24 |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Grant 9,187,479 - Clareen , et al. November 17, 2 | 2015-11-17 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20150297605 - TROWE; Torsten | 2015-10-22 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20150297590 - FULTZ; Kimberly Elizabeth ; et al. | 2015-10-22 |
SOLID FORMS OF 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
App 20150299209 - BOERSEN; Nathan ; et al. | 2015-10-22 |
SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
App 20150299207 - ECKERT; Jeffrey | 2015-10-22 |
SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-- 3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
App 20150299208 - KLOPFER; Kevin | 2015-10-22 |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
Grant 9,156,798 - Bahmanyar , et al. October 13, 2 | 2015-10-13 |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
Grant 9,155,736 - Xu , et al. October 13, 2 | 2015-10-13 |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
Grant 9,139,534 - Bennett , et al. September 22, 2 | 2015-09-22 |
Substituted Diaminopyrimidyl Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20150246890 - BAHMANYAR; Sogole ; et al. | 2015-09-03 |
Solid Forms Of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyri- Midine-5-carboxamide, Compositions Thereof And Methods Of Their Use
App 20150210650 - Ferretti; Antonio Christian ; et al. | 2015-07-30 |
Methods of synthesis and purification of heteroaryl compounds
Grant 9,079,900 - Harris , et al. July 14, 2 | 2015-07-14 |
Substituted Diaminopyrimidyl Compounds, Compositions Thereof, And Methods Of Treatment Therewith
App 20150175557 - Papa; Patrick ; et al. | 2015-06-25 |
Treatment Of Cancer Characterized By Gene Mutations
App 20150099754 - Xu; Shuichan ; et al. | 2015-04-09 |
PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
App 20150051397 - Perrin-Ninkovic; Sophie ; et al. | 2015-02-19 |
Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Grant 8,907,087 - Perrin-Ninkovic , et al. December 9, 2 | 2014-12-09 |
Pharmaceutical Compositions Of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, A Solid Form Thereof And Methods Of Their Use
App 20140356430 - BEAUCHAMPS; Marie Georges ; et al. | 2014-12-04 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20140315848 - RAYMON; HEATHER | 2014-10-23 |
Treatment Of Cancer With Dihydropyrazino-pyrazines
App 20140315907 - RAYMON; HEATHER ; et al. | 2014-10-23 |
Treatment Of Cancer With Dihydropyrazino-pyrazines
App 20140314673 - RAYMON; HEATHER ; et al. | 2014-10-23 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20140314753 - HEGE; KRISTEN MAE ; et al. | 2014-10-23 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20140314752 - LOPEZ-GIRONA; ANTONIA ; et al. | 2014-10-23 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20140314751 - HEGE; KRISTEN MAE ; et al. | 2014-10-23 |
Treatment Of Cancer With Dihydropyrazino-pyrazines
App 20140314674 - RAYMON; HEATHER ; et al. | 2014-10-23 |
Methods For Treating Cancer Using Dihydropyrazino-pyrazine Compound Combination Therapy
App 20140315900 - RAYMON; HEATHER ; et al. | 2014-10-23 |
PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE
App 20140315908 - Menon; Anil ; et al. | 2014-10-23 |
Haloaryl Substituted Aminopurines, Compositions Thereof,and Methods Of Treatment Therewith
App 20140206697 - CLAREEN; STEVEN ; et al. | 2014-07-24 |
Methods Of Synthesis And Purification Of Heteroaryl Compounds
App 20140155593 - Harris; Roy L. ; et al. | 2014-06-05 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20140113904 - Mortensen; Deborah ; et al. | 2014-04-24 |
Inhibition Of Phosphorylation Of Pras40, Gsk3-beta Or P70s6k1 As A Marker For Tor Kinase Inhibitory Activity
App 20140113905 - Xu; Weiming ; et al. | 2014-04-24 |
Pharmaceutical Formulations Of A Substituted Diaminopurine
App 20140093566 - Bhat; Sreenivas S. ; et al. | 2014-04-03 |
Methods of synthesis and purification of heteroaryl compounds
Grant 8,686,135 - Jokiel , et al. April 1, 2 | 2014-04-01 |
Methods of treatment, improvement and prevention using haloaryl substituted aminopurines
Grant 8,680,076 - Bennett , et al. March 25, 2 | 2014-03-25 |
Pharmaceutical formulations of a substituted diaminopurine
Grant 8,603,527 - Bhat , et al. December 10, 2 | 2013-12-10 |
PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY
App 20130289271 - Perrin-Ninkovic; Sophie ; et al. | 2013-10-31 |
Methods of synthesis and purification of heteroaryl compounds
Grant 8,569,494 - Harris , et al. October 29, 2 | 2013-10-29 |
Methods Of Synthesis And Purification Of Heteroaryl Compounds
App 20130245254 - Harris; Roy L. ; et al. | 2013-09-19 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20130245027 - Xu; Shuichan ; et al. | 2013-09-19 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20130245026 - Xu; Shuichan ; et al. | 2013-09-19 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20130245028 - Xu; Shuichan ; et al. | 2013-09-19 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20130245029 - Xu; Shuichan ; et al. | 2013-09-19 |
Haloaryl Substituted Aminopurines, Compositions Thereof,and Methods Of Treatment Therewith
App 20130225564 - CLAREEN; STEVEN ; et al. | 2013-08-29 |
Methods For Treating Cancer Using Tor Kinase Inhibitor Combination Therapy
App 20130225518 - XU; SHUICHAN ; et al. | 2013-08-29 |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitor for oncology indications and diseases associated with the mTOR/PI3K/AKT pathway
Grant 8,507,492 - Perrin-Ninkovic , et al. August 13, 2 | 2013-08-13 |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitor for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
Grant 8,492,381 - Perrin-Ninkovic , et al. July 23, 2 | 2013-07-23 |
Identification Of Gene Expression As A Predictive Biomarker For Lkb1 Status
App 20130158023 - Ning; Yuhong L. ; et al. | 2013-06-20 |
Pharmaceutical Compositions Of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, A Solid Form Thereof And Methods Of Their Use
App 20130142873 - ASSAF; MAHMOUD S. ; et al. | 2013-06-06 |
Methods of modulating inflammatory cell recruitment and gene expression using haloaryl substituted aminopurines
Grant 8,440,661 - Bennett , et al. May 14, 2 | 2013-05-14 |
Treatment Of Cancer With Tor Kinase Inhibitors
App 20130102613 - XU; SHUICHAN ; et al. | 2013-04-25 |
Methods of treatment using heteroaryl compounds and compositions thereof
Grant 8,383,634 - Mortensen , et al. February 26, 2 | 2013-02-26 |
Methods of treatment comprising the administration of heteroaryl compounds
Grant 8,372,976 - Mortensen , et al. February 12, 2 | 2013-02-12 |
Aminotriazolopyridines, compositions thereof, and methods of treatment therewith
Grant 8,299,056 - Bahmanyar , et al. October 30, 2 | 2012-10-30 |
Compounds and methods for modulating activation of NF-.kappa.B
Grant 8,263,326 - Manning , et al. September 11, 2 | 2012-09-11 |
Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9H-purin-2-y- lamino]-cyclohexan-1-ol, compositions thereof, and uses therewith
Grant 8,158,635 - Beauchamps , et al. April 17, 2 | 2012-04-17 |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
Grant 8,110,578 - Perrin-Ninkovic , et al. February 7, 2 | 2012-02-07 |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Grant 8,101,588 - Albers , et al. January 24, 2 | 2012-01-24 |
Methods Of Treatment Comprising The Administration Of Heteroaryl Compounds
App 20110245245 - Mortensen; Deborah Sue ; et al. | 2011-10-06 |
Methods Of Treatment Using Heteroaryl Compounds And Compositions Thereof
App 20110224217 - Mortensen; Deborah Sue ; et al. | 2011-09-15 |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
Grant 7,981,893 - Mortensen , et al. July 19, 2 | 2011-07-19 |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
Grant 7,968,556 - Mortensen , et al. June 28, 2 | 2011-06-28 |
Methods Of Modulating Inflammatory Cell Recruitment And Gene Expression Using Haloaryl Substituted Aminopurines
App 20100249066 - Bennett; Brydon L. ; et al. | 2010-09-30 |
Methods of treatment and prevention using haloaryl substituted aminopurines
Grant 7,759,342 - Bennett , et al. July 20, 2 | 2010-07-20 |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Grant 7,723,340 - Albers , et al. May 25, 2 | 2010-05-25 |
Methods Of Treatment Comprising The Administration Of Haloaryl Substituted Aminopurines Or Compositions Thereof
App 20090312320 - Albers; Ronald J. ; et al. | 2009-12-17 |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Grant 7,521,446 - Albers , et al. April 21, 2 | 2009-04-21 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Grant 7,442,699 - Kois , et al. October 28, 2 | 2008-10-28 |
Compounds and methods for modulation of estrogen receptors
Grant 7,435,729 - Gayo-Fung , et al. October 14, 2 | 2008-10-14 |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
Grant 7,429,599 - Satoh , et al. September 30, 2 | 2008-09-30 |
Methods for treating or preventing metastatic cancer using benzopyranone compounds
App 20080146648 - Friedman; Glenn ; et al. | 2008-06-19 |
Methods for treating or preventing cancer using Benzopyranone Compounds
Grant 7,358,274 - Friedman , et al. April 15, 2 | 2008-04-15 |
Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto
Grant 7,354,947 - Sakata , et al. April 8, 2 | 2008-04-08 |
JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
Grant 7,351,729 - Stein , et al. April 1, 2 | 2008-04-01 |
Methods for treating inflammatory conditions or inhibiting JNK
Grant 7,335,676 - Bennett , et al. February 26, 2 | 2008-02-26 |
Compounds and methods for modulation of estrogen receptors
Grant 7,279,489 - Bhagwat , et al. October 9, 2 | 2007-10-09 |
Benzopyranone compounds, compositions thereof, and methods of treatment therewith
Grant 7,247,646 - McKie , et al. July 24, 2 | 2007-07-24 |
Combination therapy for treating or managing acute myelocytic leukemia
App 20070149571 - Stein; Bernd M. ; et al. | 2007-06-28 |
Methods of using indazole derivatives as JNK inhibitors
Grant 7,220,771 - Bhagwat , et al. May 22, 2 | 2007-05-22 |
Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
Grant 7,211,594 - Bhagwat , et al. May 1, 2 | 2007-05-01 |
Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
Grant 7,208,513 - Bhagwat , et al. April 24, 2 | 2007-04-24 |
Methods for treating, preventing and managing chronic lymphocytic leukemia with indazole compounds
App 20070060616 - Bennett; Brydon ; et al. | 2007-03-15 |
Compounds and methods for modulating activation of NF-.kappa.B
Grant 7,186,503 - Manning , et al. March 6, 2 | 2007-03-06 |
Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis
Grant 7,148,252 - Zeldis December 12, 2 | 2006-12-12 |
Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
Grant 7,129,242 - Satoh , et al. October 31, 2 | 2006-10-31 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Grant 7,122,544 - Kois , et al. October 17, 2 | 2006-10-17 |
Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto
Grant 7,119,114 - Bennett , et al. October 10, 2 | 2006-10-10 |
Methods for treating or preventing cancer using Benzopyranone compounds
App 20060194866 - Friedman; Glenn ; et al. | 2006-08-31 |
Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
Grant 7,091,235 - Friedman , et al. August 15, 2 | 2006-08-15 |
Compounds useful for the treatment of cancer, compositions thereof and methods therewith
App 20060142352 - McKenna; Jeffrey ; et al. | 2006-06-29 |
Compounds useful for the treatment of cancer, compositions thereof and methods therewith
Grant 7,037,936 - McKenna , et al. May 2, 2 | 2006-05-02 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
App 20060030576 - Kois; Adam ; et al. | 2006-02-09 |
Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related
Grant 6,987,184 - Sakata , et al. January 17, 2 | 2006-01-17 |
Method for the affinity isolation of newly synthesized RNA
Grant 6,960,438 - Pardinas , et al. November 1, 2 | 2005-11-01 |
Human mesencephalon cell lines and methods of use therefor
Grant 6,913,925 - Sah , et al. July 5, 2 | 2005-07-05 |
Human CNS cell lines and methods of use therefor
App 20050037495 - Sah, Dinah W. Y. ; et al. | 2005-02-17 |
Methods for treating inflammatory conditions or inhibiting JNK
App 20040092562 - Sakata, Steven T. ; et al. | 2004-05-13 |
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