Patent | Date |
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Engineered Meganucleases Specific For Recognition Sequences In The Hepatitis B Virus Genome App 20220243187 - Jantz; Derek ;   et al. | 2022-08-04 |
Nucleic Acid Molecules Encoding An Engineered Antigen Receptor And An Inhibitory Nucleic Acid Molecule And Methods Of Use Thereof App 20220228115 - Hux; Joann ;   et al. | 2022-07-21 |
Engineered Nucleases Useful For Treatment Of Hemophilia A App 20220193267 - Jantz; Derek ;   et al. | 2022-06-23 |
Nucleic Acids Encoding Engineered Meganucleases With Recognition Sequences Found In The Human T Cell Receptor Alpha Constant Region Gene App 20220152112 - Nicholson; Michael G. ;   et al. | 2022-05-19 |
Treatment Of Retinitis Pigmentosa Using Engineered Meganucleases App 20220143155 - Bartsevich; Victor ;   et al. | 2022-05-12 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20220145251 - Jantz; Derek ;   et al. | 2022-05-12 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20220135945 - Jantz; Derek ;   et al. | 2022-05-05 |
Genetically-modified Cells Comprising A Modified Transferrin Gene App 20220119786 - Gorsuch; Cassandra ;   et al. | 2022-04-21 |
Co-stimulatory domains for use in genetically-modified cells Grant 11,286,291 - Jantz , et al. March 29, 2 | 2022-03-29 |
Genetic Modification Of The Hydroxyacid Oxidase 1 Gene For Treatment Of Primary Hyperoxaluria App 20220090047 - Davey; Roshni ;   et al. | 2022-03-24 |
Engineered nucleases useful for treatment of hemophilia A Grant 11,278,632 - Jantz , et al. March 22, 2 | 2022-03-22 |
Engineered meganucleases specific for recognition sequences in the Hepatitis B virus genome Grant 11,274,285 - Jantz , et al. March 15, 2 | 2022-03-15 |
Nucleic acids encoding engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene Grant 11,266,693 - Nicholson , et al. March 8, 2 | 2022-03-08 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 11,268,065 - Jantz , et al. March 8, 2 | 2022-03-08 |
Fusion Molecules Of Rationally-designed Dna-binding Proteins And Effector Domains App 20210332338 - Jantz; Derek ;   et al. | 2021-10-28 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20210284980 - Smith; James Jefferson ;   et al. | 2021-09-16 |
Genetically-modified T Cells Comprising A Modified Intron In The T Cell Receptor Alpha Gene App 20210277373 - Jantz; Derek ;   et al. | 2021-09-09 |
Precise Deletion Of Chromosomal Sequences In Vivo And Treatment Of Nucleotide Repeat Expansion Disorders Using Engineered Nucleases App 20210228693 - Smith; James Jefferson ;   et al. | 2021-07-29 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20210207093 - Jantz; Derek ;   et al. | 2021-07-08 |
Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene Grant 11,053,484 - Jantz , et al. July 6, 2 | 2021-07-06 |
Engineered Meganucleases Specific For Recognition Sequences In The Hepatitis B Virus Genome App 20210180038 - Jantz; Derek ;   et al. | 2021-06-17 |
Dystrophin Gene Exon Deletion Using Engineered Nucleases App 20210145940 - Jantz; Derek ;   et al. | 2021-05-20 |
Recognition Sequences For I-crei-derived Meganucleases And Uses Thereof App 20210130874 - Jantz; Derek ;   et al. | 2021-05-06 |
Methods For Producing A Complex Transgenic Trait Locus App 20210062201 - CIGAN; ANDREW MARK ;   et al. | 2021-03-04 |
Engineered Meganucleases With Recognition Sequences Found In The Human T Cell Receptor Alpha Constant Region Gene App 20210052650 - Nicholson; Michael G. ;   et al. | 2021-02-25 |
Rationally-designed Single-chain Meganucleases With Non-palindromic Recognition Sequences App 20210054354 - Smith; James Jefferson ;   et al. | 2021-02-25 |
Engineered Meganucleases With Recognition Sequences Found In The Human Beta-2 Microglobulin Gene App 20210032664 - Bartsevich; Victor ;   et al. | 2021-02-04 |
Treatment Of Retinitis Pigmentosa Using Engineered Meganucleases App 20210000928 - Bartsevich; Victor ;   et al. | 2021-01-07 |
Co-stimulatory Domains For Use In Genetically-modified Cells App 20200399346 - Jantz; Derek ;   et al. | 2020-12-24 |
Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome Grant 10,851,358 - Jantz , et al. December 1, 2 | 2020-12-01 |
Methods for producing a complex transgenic trait locus Grant 10,822,610 - Cigan , et al. November 3, 2 | 2020-11-03 |
Nucleic Acid Molecules Encoding An Engineered Antigen Receptor And An Inhibitory Nucleic Acid Molecule And Methods Of Use Thereof App 20200339952 - Hux; Joann ;   et al. | 2020-10-29 |
Co-stimulatory domains for use in genetically-modified cells Grant 10,800,833 - Jantz , et al. October 13, 2 | 2020-10-13 |
Engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene Grant 10,799,535 - Nicholson , et al. October 13, 2 | 2020-10-13 |
Self-limiting Viral Vectors Encoding Nucleases App 20200308602 - Jantz; Derek ;   et al. | 2020-10-01 |
Engineered Nucleases That Target Human And Canine Factor Viii Genes As A Treatment For Hemophilia A App 20200299658 - Hekele; Armin ;   et al. | 2020-09-24 |
Treatment of retinitis pigmentosa using engineered meganucleases Grant 10,758,595 - Bartsevich , et al. Sep | 2020-09-01 |
Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof Grant 10,745,665 - Hux , et al. A | 2020-08-18 |
Modified Epidermal Growth Factor Receptor Peptides For Use In Genetically-modified Cells App 20200239544 - Jantz; Derek ;   et al. | 2020-07-30 |
Engineered Meganucleases Specific For Recognition Sequences In The Hepatitis B Virus Genome App 20200239864 - Jantz; Derek ;   et al. | 2020-07-30 |
Treatment Of Retinitis Pigmentosa Using Engineered Meganucleases App 20200179495 - Bartsevich; Victor ;   et al. | 2020-06-11 |
Self-limiting viral vectors encoding nucleases Grant 10,662,440 - Jantz , et al. | 2020-05-26 |
Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome Grant 10,662,416 - Jantz , et al. | 2020-05-26 |
Engineered Meganucleases Specific For Recognition Sequences In The Pcsk9 Gene App 20200131489 - Bartsevich; Victor ;   et al. | 2020-04-30 |
Genetically-modified T Cells Comprising A Modified Intron In The T Cell Receptor Alpha Gene App 20200123516 - Jantz; Derek ;   et al. | 2020-04-23 |
Fusion Molecules Of Rationally-designed Dna-binding Proteins And Effector Domains App 20200109384 - Jantz; Derek ;   et al. | 2020-04-09 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20200109383 - Smith; James Jefferson ;   et al. | 2020-04-09 |
Treatment of retinitis pigmentosa using engineered meganucleases Grant 10,603,363 - Bartsevich , et al. | 2020-03-31 |
Nucleic Acid Molecules Encoding An Engineered Antigen Receptor And An Inhibitory Nucleic Acid Molecule And Methods Of Use Thereo App 20200063102 - Hux; Joann ;   et al. | 2020-02-27 |
Co-stimulatory Domains For Use In Genetically-modified Cells App 20200031904 - Jantz; Derek ;   et al. | 2020-01-30 |
Dystrophin Gene Exon Deletion Using Engineered Nucleases App 20190365870 - Jantz; Derek ;   et al. | 2019-12-05 |
Engineered Meganucleases Specific For Recognition Sequences In The Hepatitis B Virus Genome App 20190284543 - Jantz; Derek ;   et al. | 2019-09-19 |
Dystrophin Gene Exon Deletion Using Engineered Nucleases App 20190269762 - Jantz; Derek ;   et al. | 2019-09-05 |
Methods And Products For Producing Engineered Mammalian Cell Lines With Amplified Transgenes App 20190249199 - Jantz; Derek ;   et al. | 2019-08-15 |
Co-stimulatory Domains For Use In Genetically-modified Cells App 20190233500 - Jantz; Derek ;   et al. | 2019-08-01 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20190194616 - Jantz; Derek ;   et al. | 2019-06-27 |
Recognition Sequences For I-crei-derived Meganucleases And Uses Thereof App 20190194729 - Jantz; Derek ;   et al. | 2019-06-27 |
Engineered Nucleases Useful For Treatment Of Hemophilia A App 20190142973 - Jantz; Derek ;   et al. | 2019-05-16 |
Recognition sequences for I-CreI-derived meganucleases and uses thereof Grant 10,287,626 - Jantz , et al. | 2019-05-14 |
Recognition sequences for I-CreI-derived meganucleases and uses thereof Grant 10,273,524 - Jantz , et al. | 2019-04-30 |
Engineered Meganucleases With Recognition Sequences Found In The Human Beta-2 Microglobulin Gene App 20190017075 - Bartsevich; Victor ;   et al. | 2019-01-17 |
Precise Deletion Of Chromosomal Sequences In Vivo And Treatment Of Nucleotide Repeat Expansion Disorders Using Engineered Nucleases App 20180344817 - Smith; James Jefferson ;   et al. | 2018-12-06 |
Rationally-designed Single-chain Meganucleases With Non-palindromic Recognition Sequences App 20180340160 - Smith; James Jefferson ;   et al. | 2018-11-29 |
Methods For Producing A Complex Transgenic Trait Locus App 20180305706 - Cigan; Andrew Mark ;   et al. | 2018-10-25 |
Engineered Meganucleases With Recognition Sequences Found In The Human T Cell Receptor Alpha Constant Region Gene App 20180289741 - Nicholson; Michael G. ;   et al. | 2018-10-11 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 10,093,899 - Jantz , et al. October 9, 2 | 2018-10-09 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 10,093,900 - Jantz , et al. October 9, 2 | 2018-10-09 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20180265845 - Jantz; Derek ;   et al. | 2018-09-20 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20180258392 - Jantz; Derek ;   et al. | 2018-09-13 |
Treatment Of Retinitis Pigmentosa Using Engineered Meganucleases App 20180250370 - Bartsevich; Victor ;   et al. | 2018-09-06 |
Rationally-designed single-chain meganucleases with non-palindromic recognition sequences Grant 10,041,053 - Smith , et al. August 7, 2 | 2018-08-07 |
Methods for producing a complex transgenic trait locus Grant 10,030,245 - Lassner , et al. July 24, 2 | 2018-07-24 |
Self-limiting Viral Vectors Encoding Nucleases App 20180171357 - Jantz; Derek ;   et al. | 2018-06-21 |
Methods And Products For Producing Engineered Mammalian Cell Lines With Amplified Transgenes App 20180163233 - Jantz; Derek ;   et al. | 2018-06-14 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,993,501 - Jantz , et al. June 12, 2 | 2018-06-12 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,993,502 - Jantz , et al. June 12, 2 | 2018-06-12 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20180140635 - Jantz; Derek ;   et al. | 2018-05-24 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20180133254 - Jantz; Derek ;   et al. | 2018-05-17 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,969,975 - Jantz , et al. May 15, 2 | 2018-05-15 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,950,010 - Jantz , et al. April 24, 2 | 2018-04-24 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,950,011 - Jantz , et al. April 24, 2 | 2018-04-24 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,889,160 - Jantz , et al. February 13, 2 | 2018-02-13 |
Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Grant 9,889,161 - Jantz , et al. February 13, 2 | 2018-02-13 |
Fusion Molecules Of Rationally-designed Dna-binding Proteins And Effector Domains App 20180023065 - Jantz; Derek ;   et al. | 2018-01-25 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20170333481 - Jantz; Derek ;   et al. | 2017-11-23 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20170335299 - SMITH; James Jefferson ;   et al. | 2017-11-23 |
Genetically-modified Cells Comprising A Modified Human T Cell Receptor Alpha Constant Region Gene App 20170335010 - Jantz; Derek ;   et al. | 2017-11-23 |
Methods and products for producing engineered mammalian cell lines with amplified transgenes Grant 9,822,381 - Jantz , et al. November 21, 2 | 2017-11-21 |
Recognition Sequences For I-crei-derived Meganucleases And Uses Thereof App 20170298420 - JANTZ; Derek ;   et al. | 2017-10-19 |
Recognition Sequences For I-crei-derived Meganucleases And Uses Thereof App 20170298419 - JANTZ; Derek ;   et al. | 2017-10-19 |
Recognition sequences for I-CreI-derived meganucleases and uses thereof Grant 9,683,257 - Jantz , et al. June 20, 2 | 2017-06-20 |
Dystrophin Gene Exon Deletion Using Engineered Nucleases App 20170106055 - JANTZ; Derek ;   et al. | 2017-04-20 |
Methods And Compositions For Producing Male Sterile Plants App 20170058295 - BIDNEY; DENNIS L. ;   et al. | 2017-03-02 |
Methods and compositions for producing male sterile plants Grant 9,574,208 - Bidney , et al. February 21, 2 | 2017-02-21 |
Methods and compositions for producing male sterile plants Grant 9,499,837 - Bidney , et al. November 22, 2 | 2016-11-22 |
Rationally-designed single-chain meganucleases with non-palindromic recognition sequences Grant 9,434,931 - Smith , et al. September 6, 2 | 2016-09-06 |
Rationally-designed Single-chain Meganucleases With Non-palindromic Recognition Sequences App 20160222417 - SMITH; James Jefferson ;   et al. | 2016-08-04 |
Rationally-designed single-chain meganucleases with non-palindromic recognition sequences Grant 9,340,777 - Smith , et al. May 17, 2 | 2016-05-17 |
Methods And Products For Producing Engineered Mammalian Cell Lines With Amplified Transgenes App 20160017372 - JANTZ; Derek ;   et al. | 2016-01-21 |
Rationally-designed Single-chain Meganucleases With Non-palindromic Recognition Sequences App 20160002671 - SMITH; James Jefferson ;   et al. | 2016-01-07 |
Rationally-designed Single-chain Meganucleases With Non-palindromic Recognition Sequences App 20160002615 - SMITH; James Jefferson ;   et al. | 2016-01-07 |
Rationally-Designed Single-Chain Meganucleases With Non-Palindromic Recognition Sequences App 20150337335 - SMITH; James Jefferson ;   et al. | 2015-11-26 |
Fusion Molecules of Rationally-Designed DNA-Binding Proteins and Effector Domains App 20150315556 - JANTZ; Derek ;   et al. | 2015-11-05 |
Methods And Compositions For Producing Male Sterile Plants App 20150184194 - Bidney; Dennis L. ;   et al. | 2015-07-02 |
Rationally Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity App 20150135345 - SMITH; James Jefferson ;   et al. | 2015-05-14 |
Recognition Sequences For I-crei-derived Meganucleases And Uses Thereof App 20150050655 - JANTZ; Derek ;   et al. | 2015-02-19 |
Methods and Products for Producing Engineered Mammalian Cell Lines With Amplified Transgenes App 20140179005 - JANTZ; Derek ;   et al. | 2014-06-26 |
Methods And Compositions For Producing Male Sterile Plants App 20140020131 - Bidney; Dennis L. ;   et al. | 2014-01-16 |
Fusion Molecules of Rationally-Designed DNA-Binding Proteins and Effector Domains App 20140010797 - JANTZ; Derek ;   et al. | 2014-01-09 |
Temperature-Dependent Meganuclease Activity App 20130340121 - SMITH; James Jefferson ;   et al. | 2013-12-19 |
Rationally-Designed Single-Chain Meganucleases With Non-Palindromic Recognition Sequences App 20130267009 - SMITH; James Jefferson ;   et al. | 2013-10-10 |
Methods For Producing A Complex Transgenic Trait Locus App 20130263324 - Lassner; Michael ;   et al. | 2013-10-03 |
Rationally-designed Meganucleases With Recognition Sequences Found In Dnase Hypersensitive Regions Of The Human Genome App 20130224863 - JANTZ; Derek ;   et al. | 2013-08-29 |
Rationally Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity App 20130227720 - SMITH; James Jefferson ;   et al. | 2013-08-29 |
Rationally-designed single-chain meganucleases with non-palindromic recognition sequences Grant 8,445,251 - Smith , et al. May 21, 2 | 2013-05-21 |
Method for producing genetically-modified cells with rationally-designed meganucleases with altered sequence specificity Grant 8,377,674 - Smith , et al. February 19, 2 | 2013-02-19 |
Rationally-designed meganuclease variants of lig-34 and I-crei for maize genome engineering Grant 8,338,157 - Jantz , et al. December 25, 2 | 2012-12-25 |
Rationally-designed meganucleases with altered sequence specificity and heterodimer formation Grant 8,304,222 - Smith , et al. November 6, 2 | 2012-11-06 |
Rationally-Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity App 20120264189 - Smith; James J. ;   et al. | 2012-10-18 |
Methods Of Producing Genetically-modified Eukaryotic Cells With Rationally-designed Meganucleases App 20120266266 - SMITH; James J. ;   et al. | 2012-10-18 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,163,514 - Smith , et al. April 24, 2 | 2012-04-24 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,148,098 - Smith , et al. April 3, 2 | 2012-04-03 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,143,015 - Smith , et al. March 27, 2 | 2012-03-27 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,143,016 - Smith , et al. March 27, 2 | 2012-03-27 |
Rationally Designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120070877 - Smith; James J. ;   et al. | 2012-03-22 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,133,697 - Smith , et al. March 13, 2 | 2012-03-13 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,129,134 - Smith , et al. March 6, 2 | 2012-03-06 |
Method of cleaving DNA with rationally-designed meganucleases Grant 8,124,369 - Smith , et al. February 28, 2 | 2012-02-28 |
Methods of cleaving DNA with rationally-designed meganucleases Grant 8,119,361 - Smith , et al. February 21, 2 | 2012-02-21 |
Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity Grant 8,119,381 - Smith , et al. February 21, 2 | 2012-02-21 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120040405 - Smith; James J. ;   et al. | 2012-02-16 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120040406 - Smith; James J. ;   et al. | 2012-02-16 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120028314 - Smith; James J. ;   et al. | 2012-02-02 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120028315 - Smith; James J. ;   et al. | 2012-02-02 |
Rationally Designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120030783 - Smith; James J. ;   et al. | 2012-02-02 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120021465 - Smith; James J. ;   et al. | 2012-01-26 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120021521 - Smith; James J. ;   et al. | 2012-01-26 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120021520 - Smith; James J. ;   et al. | 2012-01-26 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120015406 - Smith; James J. ;   et al. | 2012-01-19 |
Rationally-designed Meganucleases With Altered Sequence Specificity And Dna-binding Affinity App 20120015421 - Smith; James J. ;   et al. | 2012-01-19 |
Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity Grant 8,021,867 - Smith , et al. September 20, 2 | 2011-09-20 |
Recognition Sequences For I-crei-derived Meganucleases And Uses Thereof App 20110202479 - JANTZ; Derek ;   et al. | 2011-08-18 |
Fusion Molecules Of Rationally-designed Dna-binding Proteins And Effector Domains App 20110123509 - JANTZ; Derek ;   et al. | 2011-05-26 |
Rationally-designed Meganucleases For Maize Genome Engineering App 20110113509 - JANTZ; Derek ;   et al. | 2011-05-12 |
Rationally-designed Meganucleases With Recognition Sequences Found In Dnase Hypersensitive Regions Of The Human Genome App 20110033935 - Jantz; Derek ;   et al. | 2011-02-10 |
Rationally-designed Single-chain Meganucleases With Non-palindromic Recognition Sequences App 20100311817 - Smith; James J. ;   et al. | 2010-12-09 |
Temperature-dependent Meganuclease Activity App 20100071083 - Smith; James J. ;   et al. | 2010-03-18 |
Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity App 20070117128 - Smith; James J. ;   et al. | 2007-05-24 |