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Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Grant 11,439,666 - Bonini , et al. September 13, 2 | 2022-09-13 |
Methods and compositions for targeted cleavage and recombination Grant 11,311,574 - Holmes , et al. April 26, 2 | 2022-04-26 |
Methods and compositions for modulating PD1 Grant 11,235,026 - Gregory , et al. February 1, 2 | 2022-02-01 |
T cell modifying compounds and uses thereof Grant 11,236,175 - Gregory , et al. February 1, 2 | 2022-02-01 |
Method Of Inactivating A Glucocorticoid Receptor Gene In An Isolated Cell App 20210102222 - Reik; Andreas ;   et al. | 2021-04-08 |
Methods And Compositions For Modification Of A Hla Locus App 20210054046 - Collingwood; Trevor ;   et al. | 2021-02-25 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Grant 10,918,668 - Gregory , et al. February 16, 2 | 2021-02-16 |
Isolated human cell with an inactivated glucocorticoid receptor gene Grant 10,907,175 - Reik , et al. February 2, 2 | 2021-02-02 |
Methods And Compositions For Producing Hepatocytes App 20210024885 - Yi; Fei ;   et al. | 2021-01-28 |
Methods and compositions for modification of a HLA locus Grant 10,858,416 - Collingwood , et al. December 8, 2 | 2020-12-08 |
Methods And Compositions For Targeted Cleavage And Recombination App 20200297762 - Holmes; Michael C. ;   et al. | 2020-09-24 |
Methods And Compositions For Engineering Immunity App 20200282079 - Holmes; Michael C. ;   et al. | 2020-09-10 |
Methods and compositions for increased transgene expression Grant 10,717,993 - Holmes , et al. | 2020-07-21 |
Methods and compositions for targeted cleavage and recombination Grant 10,675,302 - Holmes , et al. | 2020-06-09 |
Methods and compositions for engineering immunity Grant 10,639,383 - Holmes , et al. | 2020-05-05 |
Delivery methods and compositions for nuclease-mediated genome engineering Grant 10,604,771 - Cannon , et al. | 2020-03-31 |
Delivery methods and compositions for nuclease-mediated genome engineering Grant 10,494,648 - Holmes , et al. De | 2019-12-03 |
Methods And Compositions For Nuclease-mediated Targeted Integration App 20190352671 - Holmes; Michael C. ;   et al. | 2019-11-21 |
B-cell Engineering App 20190352614 - Amora; Rainier ;   et al. | 2019-11-21 |
Method of treating factor IX deficiency using nuclease-mediated targeted integration Grant 10,370,680 - Holmes , et al. | 2019-08-06 |
Methods And Compositions For The Treatment Of Rare Diseases App 20190167815 - Holmes; Michael C. ;   et al. | 2019-06-06 |
Targeted Disruption Of T Cell Receptor Genes Using Engineered Zinc Finger Protein Nucleases App 20190046579 - Bonini; Maria Chiara ;   et al. | 2019-02-14 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Grant 10,155,011 - Bonini , et al. Dec | 2018-12-18 |
Methods And Compositions For Modulating Pd1 App 20180326000 - Gregory; Philip D. ;   et al. | 2018-11-15 |
Methods And Compositions For Modification Of A Hla Locus App 20180319864 - Collingwood; Trevor ;   et al. | 2018-11-08 |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells Grant 10,117,899 - Genovese , et al. November 6, 2 | 2018-11-06 |
Methods And Compositions For Gene Inactivation App 20180312826 - Ando; Dale ;   et al. | 2018-11-01 |
Methods and compositions for modification of a HLA locus Grant 10,072,062 - Collingwood , et al. September 11, 2 | 2018-09-11 |
Methods and compositions for modulating PD1 Grant 10,046,028 - Gregory , et al. August 14, 2 | 2018-08-14 |
Methods And Compositions For Treatment Of A Genetic Condition App 20180223311 - Cost; Gregory J. ;   et al. | 2018-08-09 |
Targeted Disruption Of T Cell Receptor Genes Using Engineered Zinc Finger Protein Nucleases App 20180214485 - Gregory; Philip D. ;   et al. | 2018-08-02 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering App 20180216136 - Holmes; Michael C. ;   et al. | 2018-08-02 |
Delivery Of Target Specific Nucleases App 20180185516 - Ansell; Steven M. ;   et al. | 2018-07-05 |
Methods and compositions for treatment of a genetic condition Grant 9,963,715 - Cost , et al. May 8, 2 | 2018-05-08 |
Delivery methods and compositions for nuclease-mediated genome engineering Grant 9,957,526 - Holmes , et al. May 1, 2 | 2018-05-01 |
Targeted disruption of T cell receptor genes using talens Grant 9,937,207 - Gregory , et al. April 10, 2 | 2018-04-10 |
Targeted integration into stem cells Grant 9,834,787 - Gregory , et al. December 5, 2 | 2017-12-05 |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells Grant 9,833,479 - Conway , et al. December 5, 2 | 2017-12-05 |
Methods And Compositions For Targeted Cleavage And Recombination App 20170326174 - Holmes; Michael C. ;   et al. | 2017-11-16 |
Methods and compositions for targeted cleavage and recombination Grant 9,782,437 - Holmes , et al. October 10, 2 | 2017-10-10 |
Linear donor constructs for targeted integration Grant 9,765,360 - DeKelver , et al. September 19, 2 | 2017-09-19 |
Methods and compostions for targeted genomic deletion Grant 9,752,140 - Urnov , et al. September 5, 2 | 2017-09-05 |
Modification of CXCR4 using engineered zinc finger proteins Grant 9,717,759 - Holmes , et al. August 1, 2 | 2017-08-01 |
Methods And Compositions For Engineering Immunity App 20170196992 - Holmes; Michael C. ;   et al. | 2017-07-13 |
Gene Correction Of Scid-related Genes In Hematopoietic Stem And Progenitor Cells App 20170189450 - Conway; Anthony ;   et al. | 2017-07-06 |
T Cell Modifying Compounds And Uses Thereof App 20170183420 - Gregory; Philip D. ;   et al. | 2017-06-29 |
Methods and compositions for treatment of a genetic condition Grant 9,650,648 - Cost , et al. May 16, 2 | 2017-05-16 |
Methods and compositions for treating hemophilia B Grant 9,629,930 - Gregory , et al. April 25, 2 | 2017-04-25 |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells Grant 9,616,090 - Conway , et al. April 11, 2 | 2017-04-11 |
T cell modifying compounds and uses thereof Grant 9,597,357 - Gregory , et al. March 21, 2 | 2017-03-21 |
Methods and compositions for prevention or treatment of a disease Grant 9,574,211 - Gregory , et al. February 21, 2 | 2017-02-21 |
Methods and compositions for inhibiting viral entry into cells Grant 9,566,352 - Holmes , et al. February 14, 2 | 2017-02-14 |
Genome editing of a Rosa locus using nucleases Grant 9,567,573 - Gregory , et al. February 14, 2 | 2017-02-14 |
Methods And Compositions For Gene Inactivation App 20160326505 - Ando; Dale ;   et al. | 2016-11-10 |
Methods and compositions for gene inactivation Grant 9,434,776 - Ando , et al. September 6, 2 | 2016-09-06 |
Linear Donor Constructs For Targeted Integration App 20160237457 - DeKelver; Russell ;   et al. | 2016-08-18 |
Methods And Compositions For Modulating Pd1 App 20160220634 - Gregory; Philip D. ;   et al. | 2016-08-04 |
Methods and compositions for modulating PD1 Grant 9,402,879 - Gregory , et al. August 2, 2 | 2016-08-02 |
Methods And Compositions For Increased Transgene Expression App 20160215298 - Holmes; Michael C. ;   et al. | 2016-07-28 |
Linear donor constructs for targeted integration Grant 9,376,685 - DeKelver , et al. June 28, 2 | 2016-06-28 |
Methods and compositions for targeted cleavage and recombination Grant 9,289,451 - Urnov , et al. March 22, 2 | 2016-03-22 |
Method Of Inactivating A Glucocorticoid Receptor Gene In An Isolated Cell App 20160076056 - Reik; Andreas ;   et al. | 2016-03-17 |
Targeted integration and expression on exogenous nucleic acid sequences Grant 9,260,726 - Gregory , et al. February 16, 2 | 2016-02-16 |
Gene Correction Of Scid-related Genes In Hematopoietic Stem And Progenitor Cells App 20160030477 - Conway; Anthony ;   et al. | 2016-02-04 |
Methods And Compositions For Treating Hemophilia B App 20160022838 - Gregory; Philip D. ;   et al. | 2016-01-28 |
Methods and compositions for modification of the HPRT locus Grant 9,222,105 - Cost , et al. December 29, 2 | 2015-12-29 |
Method of inactivating a glucocorticoid receptor gene in an isolated cell Grant 9,217,026 - Reik , et al. December 22, 2 | 2015-12-22 |
Methods And Compositions For Prevention Or Treatment Of A Disease App 20150329875 - Gregory; Philip D. ;   et al. | 2015-11-19 |
Methods and compositions for treating hemophilia B Grant 9,175,280 - Gregory , et al. November 3, 2 | 2015-11-03 |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene Grant 9,161,995 - Guschin , et al. October 20, 2 | 2015-10-20 |
Methods And Compositions For Regulating Hiv Infection App 20150267223 - Holmes; Michael C. ;   et al. | 2015-09-24 |
Methods And Compositions For Modification Of A Hla Locus App 20150252094 - Collingwood; Trevor ;   et al. | 2015-09-10 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells Grant 9,121,072 - Holmes , et al. September 1, 2 | 2015-09-01 |
Methods And Compositions For Nuclease-mediated Targeted Integration App 20150240263 - Holmes; Michael C. ;   et al. | 2015-08-27 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells Grant 9,115,409 - Doyon , et al. August 25, 2 | 2015-08-25 |
Linear Donor Constructs For Targeted Integration App 20150225727 - DeKelver; Russell ;   et al. | 2015-08-13 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering In Hematopoietic Stem Cells App 20150174169 - Genovese; Pietro ;   et al. | 2015-06-25 |
Targeted Disruption Of T Cell Receptor Genes Using Engineered Zinc Finger Protein Nucleases App 20150164954 - Bonini; Maria Chiara ;   et al. | 2015-06-18 |
Linear donor constructs for targeted integration Grant 9,045,763 - DeKelver , et al. June 2, 2 | 2015-06-02 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering App 20150110762 - Holmes; Michael C. ;   et al. | 2015-04-23 |
Modification Of Cxcr4 Using Engineered Zinc Finger Proteins App 20150110757 - Holmes; Michael C. ;   et al. | 2015-04-23 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Grant 8,956,828 - Bonini , et al. February 17, 2 | 2015-02-17 |
Methods and compositions for modification of a HLA locus Grant 8,945,868 - Collingwood , et al. February 3, 2 | 2015-02-03 |
Methods and compositions for targeted integration Grant 8,936,936 - Holmes , et al. January 20, 2 | 2015-01-20 |
Methods And Compositions For Targeted Cleavage And Recombination App 20140369980 - Holmes; Michael C. ;   et al. | 2014-12-18 |
Methods and compositions for modification of the HPRT locus Grant 8,895,264 - Cost , et al. November 25, 2 | 2014-11-25 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering App 20140335063 - Cannon; Paula M. ;   et al. | 2014-11-13 |
Modification of CXCR4 using engineered zinc finger proteins Grant 8,871,905 - Holmes , et al. October 28, 2 | 2014-10-28 |
Targeted Disruption Of T Cell Receptor Genes Using Engineered Zinc Finger Protein Nucleases App 20140301990 - Gregory; Philip D. ;   et al. | 2014-10-09 |
Methods And Compositions For Increased Transgene Expression App 20140205576 - Holmes; Michael C. ;   et al. | 2014-07-24 |
Methods And Compositions For Alteration Of A Cystic Fibrosis Transmembrane Conductance Regulator (cftr) Gene App 20140205579 - Davis; Brian R. ;   et al. | 2014-07-24 |
Genome editing of a Rosa locus using zinc-finger nucleases Grant 8,771,985 - Cui , et al. July 8, 2 | 2014-07-08 |
Methods And Compositions For Muscular Dystrophies App 20140140969 - Beausejour; Christian ;   et al. | 2014-05-22 |
Methods And Compositions For Gene Inactivation App 20140127811 - Ando; Dale ;   et al. | 2014-05-08 |
T Cell Modifying Compounds And Uses Thereof App 20140120622 - Gregory; Philip D. ;   et al. | 2014-05-01 |
Methods And Compositions For Treatment Of A Genetic Condition App 20140093913 - Cost; Gregory J. ;   et al. | 2014-04-03 |
Methods And Compositions For Targeted Cleavage And Recombination App 20140086885 - Urnov; Fyodor ;   et al. | 2014-03-27 |
Methods And Compositions For Treatment Of A Genetic Condition App 20140080216 - Cost; Gregory J. ;   et al. | 2014-03-20 |
Methods And Compositions For Modulating Pd1 App 20140030240 - Gregory; Philip D. ;   et al. | 2014-01-30 |
Methods and compositions for gene inactivation Grant 8,569,253 - Ando , et al. October 29, 2 | 2013-10-29 |
Methods and compositions for modulating PD1 Grant 8,563,314 - Gregory , et al. October 22, 2 | 2013-10-22 |
Taregted Integration And Expression Of Exogenous Nucleic Acid Sequences App 20130244332 - Gregory; Philip D. ;   et al. | 2013-09-19 |
Methods and compositions for targeted cleavage and recombination Grant 8,524,500 - Urnov , et al. September 3, 2 | 2013-09-03 |
Methods and compositions for gene inactivation Grant 8,524,221 - Ando , et al. September 3, 2 | 2013-09-03 |
Rapid Screening Of Biologically Active Nucleases And Isolation Of Nuclease-modified Cells App 20130171657 - Doyon; Yannick ;   et al. | 2013-07-04 |
Methods And Compositions For Regulating Hiv Infection App 20130171732 - Holmes; Michael C. ;   et al. | 2013-07-04 |
Methods And Compositions For Alteration Of A Cystic Fibrosis Transmembrane Conductance Regulator (cftr) Gene App 20130145485 - Davis; Brian R. ;   et al. | 2013-06-06 |
Methods And Compositions For Modification Of The Hprt Locus App 20130137104 - Cost; Gregory J. ;   et al. | 2013-05-30 |
Methods And Compositions For Modification Of The Hprt Locus App 20130122591 - Cost; Gregory J. ;   et al. | 2013-05-16 |
Targeted deletion of cellular DNA sequences Grant 8,409,861 - Guschin , et al. April 2, 2 | 2013-04-02 |
Methods And Compositions For Gene Inactivation App 20120309091 - Ando; Dale ;   et al. | 2012-12-06 |
Methods and Compositions for Gene Inactivation App 20120308528 - Ando; Dale ;   et al. | 2012-12-06 |
Rapid Screening Of Biologically Active Nucleases And Isolation Of Nuclease-modified Cells App 20120237926 - Holmes; Michael C. ;   et al. | 2012-09-20 |
Methods And Compositions For Treating Hemophilia B App 20120128635 - GREGORY; Philip D. ;   et al. | 2012-05-24 |
Methods And Compositions For Inhibiting Viral Entry Into Cells App 20120093787 - HOLMES; Michael C. ;   et al. | 2012-04-19 |
Methods And Compositions For Modification Of A Hla Locus App 20120060230 - Collingwood; Trevor ;   et al. | 2012-03-08 |
Genome editing of a Rosa locus using zinc-finger nucleases App 20120017290 - Cui; Xiaoxia ;   et al. | 2012-01-19 |
Linear donor constructs for targeted integration App 20110281361 - DeKelver; Russell ;   et al. | 2011-11-17 |
Genome editing of a Rosa locus using nucleases App 20110265198 - Gregory; Philip D. ;   et al. | 2011-10-27 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells App 20110244474 - Holmes; Michael C. ;   et al. | 2011-10-06 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases App 20110158957 - Bonini; Maria Chiara ;   et al. | 2011-06-30 |
Methods and compositions for modulating PD1 App 20110136895 - Gregory; Philip D. ;   et al. | 2011-06-09 |
Methods and compositions for gene inactivation Grant 7,951,925 - Ando , et al. May 31, 2 | 2011-05-31 |
Engineered cleavage half-domains Grant 7,914,796 - Miller , et al. March 29, 2 | 2011-03-29 |
Methods and compositions for targeted cleavage and recombination Grant 7,888,121 - Urnov , et al. February 15, 2 | 2011-02-15 |
Targeted integration into stem cells App 20110027235 - Gregory; Philip D. ;   et al. | 2011-02-03 |
Methods and compositions for targeted cleavage and recombination App 20110030076 - Urnov; Fyodor ;   et al. | 2011-02-03 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells App 20110014616 - HOLMES; MICHAEL C. ;   et al. | 2011-01-20 |
Modification of CXCR4 using engineered zinc finger proteins App 20100291048 - Holmes; Michael C. ;   et al. | 2010-11-18 |
Methods and compositions for gene inactivation App 20100111907 - Ando; Dale ;   et al. | 2010-05-06 |
Linear donor constructs for targeted integration App 20090263900 - DeKelver; Russell ;   et al. | 2009-10-22 |
Methods and compositions for targeted integration App 20090117617 - Holmes; Michael C. ;   et al. | 2009-05-07 |
Methods and compositions for increased transgene expression App 20080311095 - Holmes; Michael C. ;   et al. | 2008-12-18 |
Methods and compositions for modification of the human glucocorticoid receptor locus App 20080188000 - Reik; Andreas ;   et al. | 2008-08-07 |
Methods and compositions for gene inactivation App 20080159996 - Ando; Dale ;   et al. | 2008-07-03 |
Targeted integration and expression of exogenous nucleic acid sequences App 20070134796 - Holmes; Michael C. ;   et al. | 2007-06-14 |
Targeted deletion of cellular DNA sequences App 20060188987 - Guschin; Dmitry ;   et al. | 2006-08-24 |
Methods and compositions for targeted cleavage and recombination App 20050064474 - Urnov, Fyodor ;   et al. | 2005-03-24 |