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2H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor Grant 11,400,094 - Poudel , et al. August 2, 2 | 2022-08-02 |
Antibody-drug conjugate with a tubulysin analog warhead having a stabilized acetate group in the TUV subunit Grant 11,020,490 - Young , et al. June 1, 2 | 2021-06-01 |
Modified Self-immolating Moieties For Use In Prodrugs And Conjugates And Methods Of Using And Making App 20210113706 - POUDEL; Yam B. ;   et al. | 2021-04-22 |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor Grant 10,981,914 - Young , et al. April 20, 2 | 2021-04-20 |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor Grant 10,941,145 - Poudel , et al. March 9, 2 | 2021-03-09 |
Macrocyclic Toll-like Receptor 7 (tlr7) Agonists App 20210053979 - PURANDARE; Ashok V. ;   et al. | 2021-02-25 |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor Grant 10,927,114 - He , et al. February 23, 2 | 2021-02-23 |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor Grant 10,919,895 - Poudel , et al. February 16, 2 | 2021-02-16 |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor Grant 10,913,741 - He , et al. February 9, 2 | 2021-02-09 |
Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making Grant 10,898,578 - Poudel , et al. January 26, 2 | 2021-01-26 |
Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents Grant 10,889,590 - Nicolaou , et al. January 12, 2 | 2021-01-12 |
Antiproliferative compounds and conjugates made therefrom Grant 10,869,934 - McDonald , et al. December 22, 2 | 2020-12-22 |
Toll-like Receptor 7 (tlr7) Agonists Having Heteroatom-linked Aromatic Moieties, Conjugates Thereof, And Methods And Uses Therefor App 20200392137 - HE; Liqi ;   et al. | 2020-12-17 |
Toll-like Receptor 7 (tlr7) Agonists Having A Heterobiaryl Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200317672 - HE; Liqi ;   et al. | 2020-10-08 |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor Grant 10,793,569 - He , et al. October 6, 2 | 2020-10-06 |
Toll-like Receptor 7 (tlr7) Agonists Having A Pyridine Or Pyrazine Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200308175 - POUDEL; Yam B. ;   et al. | 2020-10-01 |
Toll-like Receptor 7 (tlr7) Agonists Having A Benzotriazole Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200291028 - Poudel; Yam B. ;   et al. | 2020-09-17 |
Toll-like Receptor 7 (tlr7) Agonists Having Heteroatom-linked Aromatic Moieties, Conjugates Thereof, And Methods And Uses Theref App 20200255429 - Kind Code | 2020-08-13 |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor Grant 10,723,736 - Poudel , et al. | 2020-07-28 |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor Grant 10,711,003 - He , et al. | 2020-07-14 |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor Grant 10,696,676 - Poudel , et al. June 30, 2 | 2020-06-30 |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor Grant 10,689,382 - He , et al. | 2020-06-23 |
Toll-like Receptor 7 (tlr7) Agonists Having Heteroatom-linked Aromatic Moieties, Conjugates Thereof, And Methods And Uses Theref App 20200095248 - HE; Liqi ;   et al. | 2020-03-26 |
Toll-like Receptor 7 (tlr7) Agonists Having A Pyridine Or Pyrazine Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200048255 - POUDEL; Yam B. ;   et al. | 2020-02-13 |
Toll-like Receptor 7 (tlr7) Agonists Having A Heterobiaryl Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200048254 - HE; Liqi ;   et al. | 2020-02-13 |
1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR App 20200038403 - POUDEL; Yam B. ;   et al. | 2020-02-06 |
2H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR App 20200039986 - POUDEL; Yam B. ;   et al. | 2020-02-06 |
Toll-like Receptor 7 (tlr7) Agonists Having A Benzotriazole Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200024279 - POUDEL; Yam B. ;   et al. | 2020-01-23 |
Toll-like Receptor 7 (tlr7) Agonists Having A Tricyclic Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20200017501 - YOUNG; Ian S. ;   et al. | 2020-01-16 |
Antibody-drug Conjugate With A Tubulysin Analog Warhead Having A Stabilized Acetate Group In The Tuv Subunit App 20190388553 - Young; Ian S. ;   et al. | 2019-12-26 |
Derivatives Of Uncialamycin, Methods Of Synthesis And Their Use As Antitumor Agents App 20190382412 - Nicolaou; Kyriacos C. ;   et al. | 2019-12-19 |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor Grant 10,508,115 - He , et al. Dec | 2019-12-17 |
Modified Self-immolating Moieties For Use In Prodrugs And Conjugates And Methods Of Using And Making App 20190365915 - POUDEL; Yam B. ;   et al. | 2019-12-05 |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor Grant 10,494,370 - Poudel , et al. De | 2019-12-03 |
Antiproliferative Compounds And Conjugates Made Therefrom App 20190358339 - McDonald; Ivar M. ;   et al. | 2019-11-28 |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor Grant 10,487,084 - He , et al. Nov | 2019-11-26 |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor Grant 10,472,361 - Poudel , et al. Nov | 2019-11-12 |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor Grant 10,457,681 - Young , et al. Oc | 2019-10-29 |
Antiproliferative compounds and conjugates made therefrom Grant 10,398,783 - McDonald , et al. Sep | 2019-09-03 |
Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use Grant 10,287,291 - Yang , et al. | 2019-05-14 |
Antibody-drug conjugates of tubulysin analogs with enhanced stability Grant 10,279,049 - Cong , et al. | 2019-05-07 |
Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents Grant 10,233,192 - Nicolaou , et al. | 2019-03-19 |
Toll-like Receptor 7 (tlr7) Agonists Having A Pyridine Or Pyrazine Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20190055245 - POUDEL; Yam B. ;   et al. | 2019-02-21 |
Toll-like Receptor 7 (tlr7) Agonists Having A Heterobiaryl Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20190055246 - HE; Liqi ;   et al. | 2019-02-21 |
Toll-like Receptor 7 (tlr7) Agonists Having A Tricyclic Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20190055244 - YOUNG; Ian S. ;   et al. | 2019-02-21 |
Toll-like Receptor 7 (tlr7) Agonists Having A Benzotriazole Moiety, Conjugates Thereof, And Methods And Uses Therefor App 20190055243 - POUDEL; Yam B. ;   et al. | 2019-02-21 |
Toll-like Receptor 7 (tlr7) Agonists Having Heteroatom-linked Aromatic Moieties, Conjugates Thereof, And Methods And Uses Therefor App 20190055247 - HE; Liqi ;   et al. | 2019-02-21 |
Benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 10,112,975 - Zhang , et al. October 30, 2 | 2018-10-30 |
Tubulysin analogs and methods of making and use Grant 10,077,287 - Perez , et al. September 18, 2 | 2018-09-18 |
Antiproliferative Compounds And Conjugates Made Therefrom App 20180110873 - MCDONALD; Ivar M. ;   et al. | 2018-04-26 |
Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20180079781 - ZHANG; Yong ;   et al. | 2018-03-22 |
Derivatives Of Uncialamycin, Methods Of Synthesis And Their Use As Antitumor Agents App 20180065976 - NICOLAOU; Kyriacos C. ;   et al. | 2018-03-08 |
Seco-cyclopropapyrroloindole Compounds, Antibody-drug Conjugates Thereof, And Methods Of Making And Use App 20180051031 - YANG; Fukang ;   et al. | 2018-02-22 |
Heteroarylene-bridged Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20180037581 - MCDONALD; Ivar M. ;   et al. | 2018-02-08 |
Benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 9,822,144 - Zhang , et al. November 21, 2 | 2017-11-21 |
Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 9,822,112 - McDonald , et al. November 21, 2 | 2017-11-21 |
Antibody-drug Conjugates Of Tubulysin Analogs With Enhanced Stability App 20170326247 - CONG; Qiang ;   et al. | 2017-11-16 |
Antibody-drug Conjugate Of An Anti-glypican-3 Antibody And A Tubulysin Analog, Preparation And Uses App 20170326249 - PAN; Chin ;   et al. | 2017-11-16 |
Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents Grant 9,777,013 - Nicolaou , et al. October 3, 2 | 2017-10-03 |
Tubulysin Compounds, Methods Of Making And Use App 20170260232 - CONG; Qiang ;   et al. | 2017-09-14 |
Heteroarylene-bridged Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20170233392 - MCDONALD; Ivar M. ;   et al. | 2017-08-17 |
Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20170233436 - ZHANG; Yong ;   et al. | 2017-08-17 |
Tubulysin compounds, methods of making and use Grant 9,688,721 - Cong , et al. June 27, 2 | 2017-06-27 |
Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 9,676,775 - McDonald , et al. June 13, 2 | 2017-06-13 |
Benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 9,676,794 - Zhang , et al. June 13, 2 | 2017-06-13 |
Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20170073357 - ZHANG; Yong ;   et al. | 2017-03-16 |
Heteroarylene-bridged Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20170057959 - MCDONALD; Ivar M. ;   et al. | 2017-03-02 |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof Grant 9,580,467 - Cheng , et al. February 28, 2 | 2017-02-28 |
Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 9,526,801 - McDonald , et al. December 27, 2 | 2016-12-27 |
Benzodiazepine dimers, conjugates thereof, and methods of making and using Grant 9,527,871 - Zhang , et al. December 27, 2 | 2016-12-27 |
Tubulysin Compounds, Methods Of Making And Use App 20160264624 - CONG; Qiang ;   et al. | 2016-09-15 |
Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20160200742 - Zhang; Yong ;   et al. | 2016-07-14 |
Heteroarylene-bridged Benzodiazepine Dimers, Conjugates Thereof, And Methods Of Making And Using App 20160199510 - MCDONALD; Ivar M. ;   et al. | 2016-07-14 |
Tubulysin compounds, methods of making and use Grant 9,382,289 - Cong , et al. July 5, 2 | 2016-07-05 |
Derivatives Of Uncialamycin, Methods Of Synthesis And Their Use As Antitumor Agents App 20160185791 - NICOLAOU; Kyriacos C. ;   et al. | 2016-06-30 |
Tubulysin Analogs And Methods Of Making And Use App 20160130299 - PEREZ; Heidi L. ;   et al. | 2016-05-12 |
Antiproliferative Compounds, Conjugates Thereof, Methods Therefor, And Uses Thereof App 20160060294 - CHENG; Heng ;   et al. | 2016-03-03 |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof Grant 9,226,974 - Cheng , et al. January 5, 2 | 2016-01-05 |
Immunoconjugates, compositions for making them, and methods of making and use Grant 9,186,416 - Zhang , et al. November 17, 2 | 2015-11-17 |
Enediyne compounds, conjugates thereof, and uses and methods therefor Grant 9,156,850 - Chowdari , et al. October 13, 2 | 2015-10-13 |
Tubulysin compounds, methods of making and use Grant 9,109,008 - Cong , et al. August 18, 2 | 2015-08-18 |
Tubulysin Compounds, Methods Of Making And Use App 20150132324 - CONG; Qiang ;   et al. | 2015-05-14 |
Tubulysin compounds, methods of making and use Grant 8,980,824 - Cong , et al. March 17, 2 | 2015-03-17 |
Immunoconjugates, Compositions For Making Them, And Methods Of Making And Use App 20140364585 - ZHANG; Qian ;   et al. | 2014-12-11 |
Antiproliferative Compounds, Conjugates Thereof, Methods Therefor, And Uses Thereof App 20140323690 - Cheng; Heng ;   et al. | 2014-10-30 |
Immunoconjugates, compositions for making them, and methods of making and use Grant 8,852,599 - Zhang , et al. October 7, 2 | 2014-10-07 |
Tubulysin Compounds, Methods Of Making And Use App 20140227295 - CONG; Qiang ;   et al. | 2014-08-14 |
Tubulysin Compounds, Methods Of Making And Use App 20140227298 - CONG; Qiang ;   et al. | 2014-08-14 |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof Grant 8,802,632 - Cheng , et al. August 12, 2 | 2014-08-12 |
Enediyne Compounds, Conjugates Thereof, And Uses And Methods Therefor App 20140193438 - Chowdari; Naidu S. ;   et al. | 2014-07-10 |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof Grant 8,772,543 - Cheng , et al. July 8, 2 | 2014-07-08 |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof Grant 8,772,542 - Cheng , et al. July 8, 2 | 2014-07-08 |
Enediyne compounds, conjugates thereof, and uses and methods therefor Grant 8,709,431 - Chowdari , et al. April 29, 2 | 2014-04-29 |
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Antiproliferative Compounds, Conjugates Thereof, Methods Therefor, And Uses Thereof App 20130197259 - Cheng; Heng ;   et al. | 2013-08-01 |
Antiproliferative Compounds, Conjugates Thereof, Methods Therefor, And Uses Thereof App 20130189256 - Cheng; Heng ;   et al. | 2013-07-25 |
Chemical linkers and cleavable substrates and conjugates thereof Grant 8,461,117 - Sufi , et al. June 11, 2 | 2013-06-11 |
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Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof Grant 8,394,922 - Cheng , et al. March 12, 2 | 2013-03-12 |
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Conjugates Of Anti-rg-1 Antibodies App 20110020329 - King; David J. ;   et al. | 2011-01-27 |
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CD10-activated prodrug compounds App 20090136980 - Bebbington; Christopher R. ;   et al. | 2009-05-28 |
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Antibody-Drug Conjugates and Methods of Use App 20080279868 - Boyd; Sharon Elaine ;   et al. | 2008-11-13 |
Methods and Compounds For Preparing Cc-1065 Analogs App 20080281102 - Gangwar; Sanjeev ;   et al. | 2008-11-13 |
Prodrug compounds with isoleucine App 20080255248 - Pickford; Lesley B. ;   et al. | 2008-10-16 |
Enzyme-cleavable prodrug compounds Grant 7,425,541 - Dubois , et al. September 16, 2 | 2008-09-16 |
Prodrug compounds with isoleucine Grant 7,329,507 - Pickford , et al. February 12, 2 | 2008-02-12 |
CD-10 activated prodrug compounds Grant 7,304,032 - Bebbington , et al. December 4, 2 | 2007-12-04 |
Tripeptide prodrug compounds App 20070275903 - Bebbington; Christopher R. ;   et al. | 2007-11-29 |
Tripeptide prodrug compounds Grant 7,214,663 - Bebbington , et al. May 8, 2 | 2007-05-08 |
Prodrug compounds with isoleucine App 20070020694 - Pickford; Lesley B. ;   et al. | 2007-01-25 |
Cytotoxic compounds and conjugates with cleavable substrates App 20060247295 - Gangwar; Sanjeev ;   et al. | 2006-11-02 |
Prodrug compounds with an isoleucine Grant 7,115,573 - Pickford , et al. October 3, 2 | 2006-10-03 |
Peptidyl prodrugs and linkers and stabilizers useful therefor Grant 7,087,600 - Ng , et al. August 8, 2 | 2006-08-08 |
Chemical linkers and conjugates thereof App 20060024317 - Boyd; Sharon E. ;   et al. | 2006-02-02 |
Peptidyl prodrugs and linkers and stabilizers useful therefor App 20060013860 - Ng; Howard P. ;   et al. | 2006-01-19 |
Cytotoxic compounds and conjugates App 20060004081 - Chen; Liang ;   et al. | 2006-01-05 |
CD-10 activated prodrug compounds App 20050267016 - Bebbington, Christopher R. ;   et al. | 2005-12-01 |
CD10-activated prodrug compounds Grant 6,897,034 - Bebbington , et al. May 24, 2 | 2005-05-24 |
CD10-activated prodrug compounds App 20040087497 - Bebbington, Christopher R. ;   et al. | 2004-05-06 |
Prodrug compounds with an oligopeptide having an isoluecine residue App 20040039160 - Pickford, Lesley B. ;   et al. | 2004-02-26 |
Tripeptide prodrug compounds App 20030181359 - Bebbington, Christopher R. ;   et al. | 2003-09-25 |
Peptidyl prodrugs and linkers and stabilizers useful therefor App 20030064984 - Ng, Howard P. ;   et al. | 2003-04-03 |
Enzyme-cleavable prodrug compounds App 20020142955 - Dubois, Vincent ;   et al. | 2002-10-03 |
Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability Grant 5,672,584 - Borchardt , et al. September 30, 1 | 1997-09-30 |