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name:-0.18316912651062
name:-0.089182138442993
name:-0.0071098804473877
Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts Patent Filings

Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts

Patent Applications and Registrations

Patent applications and USPTO patent grants for Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts.The latest application filed is for "chemically inducible polypeptide polymerization".

Company Profile
7.101.89
  • Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts - Heidelberg DE
  • Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts -
  • Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts - DE DE
  • Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts - Heidelburg DE
  • Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts - N/A
*profile and listings may contain filings by different individuals or companies with the same name. Review application materials to confirm ownership/assignment.
Patent Activity
PatentDate
Chemically Inducible Polypeptide Polymerization
App 20220281931 - EBERT; Benjamin ;   et al.
2022-09-08
Aryl Hydrocarbon Receptor (ahr) Activation Signature And Methods For Determining Ahr Signaling Status
App 20220195533 - OPITZ; Christiane A. ;   et al.
2022-06-23
Optimized Parvovirus H-1 Production
App 20220169992 - LEUCHS; Barbara ;   et al.
2022-06-02
Annexin-coated particles
App 20220152149 - KRAMMER; Peter ;   et al.
2022-05-19
Use Of Bmmfi Rep Protein As A Biomarker For Prostate Cancer
App 20220091125 - BUND; Timo ;   et al.
2022-03-24
Improved Anti-FLT3 Antigen Binding Proteins
App 20220056141 - Jung; Gundram ;   et al.
2022-02-24
Use Of Bmmf1 Rep Protein As A Biomarker For Breast Cancer
App 20220034890 - BUND; Timo ;   et al.
2022-02-03
Method, system and computer program for computer-assisted evaluation of biomarkers in a tissue sample
Grant 11,238,581 - Von Neubeck , et al. February 1, 2
2022-02-01
Method And System For Augmented Imaging In Open Treatment Using Multispectral Information
App 20220008157 - Maier-Hein; Lena ;   et al.
2022-01-13
Method And System For Augmented Imaging Using Multispectral Information
App 20220012874 - Maier-Hein; Lena ;   et al.
2022-01-13
Crystal Structure of a Replication Protein encoded by a Plasmid isolated from a Multiple Sclerosis Patient
App 20210246178 - Bund; Timo ;   et al.
2021-08-12
The Core Domain Of Annexins And Uses Thereof In Antigen Delivery And Vaccination
App 20210230238 - BUJUPI; Fatmire ;   et al.
2021-07-29
Treatments Of Non-alcoholic Steatohepatitis (nash)
App 20210213042 - HEIKENWALDER; MATHIAS ;   et al.
2021-07-15
Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance
Grant 11,053,499 - Herzig , et al. July 6, 2
2021-07-06
Treatments of non-alcoholic steatohepatitis (NASH)
Grant 11,052,102 - Heikenwalder , et al. July 6, 2
2021-07-06
Synthesis of double-stranded nucleic acids
Grant 10,988,795 - Turchinovich , et al. April 27, 2
2021-04-27
Methods For The Prediction Of A Personalized Esa-dose In The Treatment Of Anemia
App 20210093696 - Rodriguez Gonzalez; Agustin ;   et al.
2021-04-01
Compositions comprising a metal source, dithiocarbamate and cyclodextrin
Grant 10,953,099 - Amtmann , et al. March 23, 2
2021-03-23
Core domain of annexins and uses thereof in antigen delivery and vaccination
Grant 10,947,283 - Bujupi , et al. March 16, 2
2021-03-16
T Cell Receptors For Tumor Specific Proteasome Splice Variants And Uses Thereof
App 20210061876 - BLANKENSTEIN; Thomas ;   et al.
2021-03-04
Cancer Immunization Platform
App 20210030856 - Eisenbach; Rachel Lea ;   et al.
2021-02-04
Use Of Bmmfi Rep Protein As Biomarker For Colorectal Cancer
App 20210003575 - BUND; Timo ;   et al.
2021-01-07
Pancreatic cancer therapy and diagnosis
Grant 10,874,685 - Jandaghi , et al. December 29, 2
2020-12-29
Methods for the prediction of a personalized ESA-dose in the treatment of anemia
Grant 10,796,799 - Rodriguez Gonzalez , et al. October 6, 2
2020-10-06
Method, System and Computer Program for Computer-Assisted Evaluation of Biomarkers in a Tissue Sample
App 20200273161 - Von Neubeck; Clare ;   et al.
2020-08-27
Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance
Grant 10,676,739 - Herzig , et al.
2020-06-09
Modulators Of Tumor Immune Resistance For The Treatment Of Cancer
App 20200164068 - KHANDELWAL; Nisit ;   et al.
2020-05-28
Labeling Of Oligonucleotide Probes By Multiple-way Ligation
App 20200087719 - LIU; Hai-Kun ;   et al.
2020-03-19
Pancreatic Cancer Therapy And Diagnosis
App 20200030356 - JANDAGHI; Pouria ;   et al.
2020-01-30
Biomarker Panel For Diagnosing Cancer
App 20200033352 - Brenner; Hermann ;   et al.
2020-01-30
Rspondins as modulators of angiogenesis and vasculogenesis
Grant 10,538,563 - Niehrs , et al. Ja
2020-01-21
Cytotoxic T Cell Response Modifiers
App 20200002706 - Beckhove; Philipp ;   et al.
2020-01-02
Rspondins As Modulators Of Angiogenesis And Vasculogenesis
App 20190359664 - Niehrs; Christof ;   et al.
2019-11-28
Compositions Comprising A Metal Source, Dithiocarbamate And Cyclodextrin
App 20190328886 - AMTMANN; Eberhard ;   et al.
2019-10-31
Biomarker panel for diagnosing cancer
Grant 10,408,839 - Brenner , et al. Sept
2019-09-10
Rep Protein As Protein Antigen For Use In Diagnostic Assays
App 20190270795 - Zur Hausen; Harald ;   et al.
2019-09-05
Binding molecules, especially antibodies, binding to L1CAM (CD171)
Grant 10,400,037 - Altevogt , et al. Sep
2019-09-03
Method For Labeling Oligonucleotide Probes
App 20190264269 - CHENG; Yong-Sheng ;   et al.
2019-08-29
Immune Modulators For Reducing Immune-resistance In Melanoma And Other Proliferative Diseases
App 20190263906 - Beckhove; Philipp ;   et al.
2019-08-29
Treatments Of Non-alcoholic Steatohepatitis (nash)
App 20190262379 - HEIKENWALDER; Mathias ;   et al.
2019-08-29
Machine Learning-Based Quantitative Photoacoustic Tomography (PAT)
App 20190192008 - Maier-Hein; Lena ;   et al.
2019-06-27
Rspondins as modulators of angiogenesis and vasculogenesis
Grant 10,273,276 - Niehrs , et al.
2019-04-30
System for Fluorescence Aided Surgery
App 20190059736 - Maier-Hein; Lena ;   et al.
2019-02-28
Modulators Of Ccr9 For Treating Tumor Resistance To Immune Responses
App 20190054110 - KHANDELWAL; Nisit ;   et al.
2019-02-21
Synthesis Of Double-stranded Nucleic Acids
App 20190032110 - TURCHINOVICH; Andrey ;   et al.
2019-01-31
PSMA Binding Antibody and Uses Therof
App 20190022205 - Salih; Helmut ;   et al.
2019-01-24
Modulators of the function of the core domain of annexins, and uses thereof in autoimmune and/or cancer therapy
App 20180275124 - KRAMMER; Peter H. ;   et al.
2018-09-27
Method And Apparatus For Imaging A Sample
App 20180266958 - Hufnagel; Lars ;   et al.
2018-09-20
Agents For Use In The Treatment Of Glioma
App 20180221479 - Osswald; Matthias ;   et al.
2018-08-09
MicroRNAs modulating the effect of glucocorticoid signaling
Grant 10,041,070 - Berriel Diaz , et al. August 7, 2
2018-08-07
Prediction-method Of Mortality Due To Treatment With Erythropoiesis Stimulating Agents
App 20180217166 - Gonzalez; Agustin Rodriguez ;   et al.
2018-08-02
Novel Promiscuous HPV16-Derived T Helper Epitopes for Immunotherapy
App 20180194810 - GRABOWSKA; Agnieszka ;   et al.
2018-07-12
Promiscuous HPV16-derived T helper epitopes for immunotherapy
Grant 9,932,371 - Grabowska , et al. April 3, 2
2018-04-03
Biomarker Panel For Diagnosing Cancer
App 20180080937 - Brenner; Hermann ;   et al.
2018-03-22
Dna-methylation Based Method For Classifying Tumor Species
App 20180066317 - PFISTER; STEFAN ;   et al.
2018-03-08
Treatment of insulin resistance through inhibitors of transcription factor TSC22D4
Grant 9,879,258 - Berriel Diaz , et al. January 30, 2
2018-01-30
Oligonucleotide Sequences Targeting Transcription FactorTSC22D4 for the Treatment of Insulin Resistance
App 20180023078 - HERZIG; Stephan ;   et al.
2018-01-25
Binding Molecules, Especially Antibodies, Binding To L1cam (cd171)
App 20170306015 - ALTEVOGT; Peter ;   et al.
2017-10-26
Method For The Detection Of Antigen Presentation
App 20170254803 - PLATTEN; Michael ;   et al.
2017-09-07
Method and devices for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries
Grant 9,752,985 - Poustka , et al. September 5, 2
2017-09-05
Mammalian Dickkopf 3 (DKK3) as Urinary Marker for Chronic Kidney Diseases
App 20170168069 - FEDERICO; Giuseppina ;   et al.
2017-06-15
S100p And Hyaluronic Acid As Biomarkers For Metastatic Breast Cancer
App 20170030912 - Burwinkel; Barbara ;   et al.
2017-02-02
Visualization of anatomical data by augmented reality
Grant 9,498,132 - Maier-Hein , et al. November 22, 2
2016-11-22
Novel Promiscuous HPV16-Derived T Helper Epitopes for Immunotherapy
App 20160311861 - GRABOWSKA; Agnieszka ;   et al.
2016-10-27
MicroRNAs Modulating the Effect of Glucocorticoid Signaling
App 20160251656 - Berriel Diaz; Mauricio ;   et al.
2016-09-01
Treatment of Insulin Resistance Through Inhibitors of Transcription Factor TSC22D4
App 20160115475 - BERRIEL DIAZ; Mauricio ;   et al.
2016-04-28
Rspondins As Modulators Of Angiogenesis And Vasculogenesis
App 20160009773 - Niehrs; Christof ;   et al.
2016-01-14
Antagonist anti-Rspondin3 antibodies
Grant 9,226,963 - Niehrs , et al. January 5, 2
2016-01-05
Rspondin antibodies as inhibiting factors of angiogenesis and vaculogenesis
Grant 8,926,970 - Niehrs , et al. January 6, 2
2015-01-06
Polynucleotide encoding a fusion polypeptide suitable as cytotoxin
Grant 8,598,326 - Nueesch , et al. December 3, 2
2013-12-03
Rspondin polypeptides as promoting factors of angiogenesis and vasculogenesis
Grant 8,580,736 - Niehrs , et al. November 12, 2
2013-11-12
Treatment of tumors using specific anti-L1 antibody
Grant 8,580,258 - Kelm , et al. November 12, 2
2013-11-12
Methods and compounds for treating diseases caused by reactive oxygen species
Grant 8,563,500 - Guelow , et al. October 22, 2
2013-10-22
Process for the covalent coupling of two molecules by means of a diels-alder reaction with inverse electron requirement
Grant 8,552,183 - Wiessler , et al. October 8, 2
2013-10-08
Visualization of Anatomical Data by Augmented Reality
App 20130245461 - Maier-Hein; Lena ;   et al.
2013-09-19
Inhibitor protein of the wnt signal pathway
Grant 8,536,311 - Niehrs , et al. September 17, 2
2013-09-17
Inhibitor protein of the wnt signal pathway
Grant 8,461,309 - Niehrs , et al. June 11, 2
2013-06-11
Imaging method and device for carrying out said method
Grant 8,361,440 - Peter January 29, 2
2013-01-29
Methods for identifying kremen polypeptide binding partners
Grant 8,227,200 - Niehrs , et al. July 24, 2
2012-07-24
Multi-modal cancer therapy using viral hitch-hiking
Grant 8,142,791 - Schirrmacher , et al. March 27, 2
2012-03-27
Treatment of tumors using specific anti-L1 antibody
Grant 8,138,313 - Kelm , et al. March 20, 2
2012-03-20
Griseofulvin Analogues For The Treatment Of Cancer By Inhibition Of Centrosomal Clustering
App 20120035200 - Kraemer; Alwin ;   et al.
2012-02-09
Compositions for diagnosis and therapy of diseases associated with aberrant expression of kremen and/or WNT
App 20110287420 - Niehrs; Christof ;   et al.
2011-11-24
CD95-Fc fusion proteins
Grant 8,007,813 - Walczak August 30, 2
2011-08-30
Preparation of solid phase bound peptides or PNAs
Grant 8,008,434 - Brandt , et al. August 30, 2
2011-08-30
Use Of Cd95 Inhibitors For The Treatment Of Inflammatory Disorders
App 20110189194 - Martin-Villalba; Ana ;   et al.
2011-08-04
Inhibition Of Angiogenesis And Tumor Metastasis
App 20110171290 - Altevogt; Peter ;   et al.
2011-07-14
Method, device and navigation aid for navigation during medical interventions
Grant 7,953,470 - Vetter , et al. May 31, 2
2011-05-31
Methods for identifying Kremen polypeptide binding partners
Grant 7,947,462 - Niehrs , et al. May 24, 2
2011-05-24
Inhibitor protein of the wnt signal pathway
App 20110118445 - Niehrs; Christof ;   et al.
2011-05-19
Inhibition of the CD95 ligand/receptor system for the treatment of neurological disorders and injuries
Grant 7,935,339 - Martin-Villalba , et al. May 3, 2
2011-05-03
Methods And Compounds For Treating Diseases Caused By Reactive Oxygen Species
App 20100305187 - Guelow; Karsten ;   et al.
2010-12-02
Heparanase-derived peptides for vaccination of tumor patients
Grant 7,842,782 - Schirrmacher , et al. November 30, 2
2010-11-30
Optical scanning device and method of deriving same
Grant 7,746,470 - Engelhardt June 29, 2
2010-06-29
Fusion Polypeptide Suitable As A Cytotoxin
App 20100144847 - Nuesch; Jurg ;   et al.
2010-06-10
Antibodies active against a fusion polypeptide comprising a histidine portion
Grant 7,713,712 - Zentgraf , et al. May 11, 2
2010-05-11
Modified HPV E6 and E7 genes and proteins useful for vaccination
Grant 7,700,114 - Cid-Arregui , et al. April 20, 2
2010-04-20
Method, System And Computer Program Product For Targeting Of A Target With An Elongate Instrument
App 20100076305 - Maier-Hein; Lena ;   et al.
2010-03-25
Diagnostic and therapeutic methods based on the L1 adhesion molecule for ovarian and endometrial tumors
Grant 7,670,601 - Altevogt , et al. March 2, 2
2010-03-02
Compositions Comprising A Parvovirus Vp1-variant And A Parvovirus Ns1 Protein For Induction Of Cytolysis
App 20100029751 - Daeffler; Laurent ;   et al.
2010-02-04
Process For The Covalent Coupling Of Two Molecules By Means Of A Diels-alder Reaction With Inverse Electron Requirement
App 20100016545 - Wiessler; Manfred ;   et al.
2010-01-21
Data warehousing, annotation and statistical analysis system
Grant 7,650,343 - Fellenberg , et al. January 19, 2
2010-01-19
Diagnostic and therapeutic methods based on the L1 adhesion molecule for ovarian and endometrial tumors
Grant 7,618,785 - Altevogt , et al. November 17, 2
2009-11-17
Cell Culture Of Keratinocytes Under Non-differentiating Conditions
App 20090280095 - Szabowski; Axel ;   et al.
2009-11-12
Antibodies Active Against A Fusion Polypeptide Comprising A Histidine Portion
App 20090221040 - ZENTGRAF; Hanswalter ;   et al.
2009-09-03
PNA conjugate for the treatment of diseases associated with HIV
Grant 7,563,761 - Braun , et al. July 21, 2
2009-07-21
Treatment Of Tumors Using Specific Anti-l1 Antibody
App 20090162355 - Gast; Daniela ;   et al.
2009-06-25
Riproximin, a Novel Type II Ribosome-Inactivating Protein and Uses Thereof
App 20090137502 - Voss; Cristina ;   et al.
2009-05-28
Diagnostic conjugate useful for intracellular imaging and for differentiating between tumor- and non-tumor cells
Grant 7,531,502 - Braun , et al. May 12, 2
2009-05-12
Inverse Treatment Planning Method
App 20090060130 - Wilkens; Jan ;   et al.
2009-03-05
Dual-modality imaging
App 20090039268 - Peter; Jorg ;   et al.
2009-02-12
Optical imaging detector
App 20090032714 - Peter; Jorg ;   et al.
2009-02-05
Conjugate for treating prokaryotic infections
Grant 7,476,658 - Braun , et al. January 13, 2
2009-01-13
Treatment Of Chemotherapy- Or Radiotherapy-resistant Tumors
App 20080299123 - Altevogt; Peter ;   et al.
2008-12-04
Production and applications for polyvalent vaccines against diseases caused by papilloma viruses
Grant 7,354,714 - Gissmann , et al. April 8, 2
2008-04-08
Heparanase-Derived peptides for Vaccination of Tumor patients
App 20070253970 - Schirrmacher; Volker ;   et al.
2007-11-01
Parvovirus vectors and their use
Grant 7,267,825 - Rommelaere , et al. September 11, 2
2007-09-11
Modified Hpv E6 And E7 Genes And Proteins Useful For Vaccination
App 20070196339 - Cid-Arregui; Angel ;   et al.
2007-08-23
Modified Hpv E6 And E7 Genes And Proteins Useful For Vaccination
App 20070190074 - Cid-Arregui; Angel ;   et al.
2007-08-16
Method and apparatus for detecting the position and the orientation of an interventional device
Grant 7,239,400 - Bock , et al. July 3, 2
2007-07-03
Modified HPV E6 and E7 genes and proteins useful for vaccination
Grant 7,201,908 - Cid-Arregui , et al. April 10, 2
2007-04-10
Use of parvovirus for brain tumor therapy
Grant 7,179,456 - Rommelaere , et al. February 20, 2
2007-02-20
AAV DNA comprising helper virus sequences
Grant 7,148,341 - Kleinschmidt , et al. December 12, 2
2006-12-12
Markable compounds for easy synthesis of 3'-[.sup.18F] fluoro-3'-deoxynucleotides, and method for their production
Grant 7,145,000 - Eisenbarth , et al. December 5, 2
2006-12-05
Livin-specific sirnas for the treatment of therapy-resistant tumors
App 20060264394 - Butz; Karin ;   et al.
2006-11-23
Inhibitor protein of the wnt signal pathway
Grant 7,138,508 - Niehrs , et al. November 21, 2
2006-11-21
Collimator for high-energy radiation and program for controlling said collimator
Grant 7,132,674 - Pastyr , et al. November 7, 2
2006-11-07
Multivalent antibody constructs
Grant 7,129,330 - Little , et al. October 31, 2
2006-10-31
Method for producing water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction
Grant 6,958,395 - Wiessler , et al. October 25, 2
2005-10-25
Device and method for fluorescence correlation spectroscopy, especially for multi-color fluorescence correlation spectroscopy
Grant 6,953,695 - Langowski October 11, 2
2005-10-11
Imaging method and device for carrying out said method
App 20050215873 - Peter, Jorg
2005-09-29
Adeno-associated virus-its diagnostic use with early abortion
Grant 6,927,281 - Kern , et al. August 9, 2
2005-08-09
Derivatization of support surfaces
Grant 6,905,724 - Beier June 14, 2
2005-06-14
Labelling compounds for the simple synthesis of 3'-[18F]fluoro-3'-deoxythymidine and a method for the production thereof
Grant 6,891,033 - Martin , et al. May 10, 2
2005-05-10
Conjugate consisting of an active substance and a non-exogenous native protein
Grant 6,812,209 - Sinn , et al. November 2, 2
2004-11-02
Method and apparatus for detecting the position and the orientation of an interventional device
App 20040199067 - Bock, Michael ;   et al.
2004-10-07
Antibodies active against a fusion polypeptide comprising a histidine portion
Grant 6,790,940 - Zentgraf , et al. September 14, 2
2004-09-14
Antibodies active against a fusion polypeptide comprising a histidine portion
App 20040105854 - Zentgraf, Hanswalter ;   et al.
2004-06-03
Use of adeno-associated viruses for decreasing the radiotherapy-induced or chemotherapy- induced resistance in cancer patients
Grant 6,743,423 - Knebel-Doeberitz , et al. June 1, 2
2004-06-01
Phagemid for antibody screening
Grant 6,730,483 - Breitling , et al. May 4, 2
2004-05-04
Conjugate comprising a folic acid antagonist and a carrier
Grant 6,720,304 - Sinn , et al. April 13, 2
2004-04-13
Contour collimator for use in radiotherapy
Grant 6,711,237 - Schlegel , et al. March 23, 2
2004-03-23
Conjugate for treating inflammatory infectious and/or skin diseases
Grant 6,706,713 - Sinn , et al. March 16, 2
2004-03-16
Mutant DEDD proteins for regulating apoptosis
Grant 6,696,547 - Peter , et al. February 24, 2
2004-02-24
Method for the light-controlled synthesis of biochips
Grant 6,673,544 - Beier , et al. January 6, 2
2004-01-06
Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
Grant 6,610,303 - de-Villiers-zur Hausen , et al. August 26, 2
2003-08-26
Method of sequencing by oligomer hybridization
Grant 6,562,566 - Hoheisel May 13, 2
2003-05-13
Phagemid for antibody screening
App 20020160463 - Breitling, Frank ;   et al.
2002-10-31
Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
App 20020110865 - Shamanin, Vladimir ;   et al.
2002-08-15
Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
App 20020110866 - Shamanin, Vladimir ;   et al.
2002-08-15
Protein for regulating apoptosis
App 20020099009 - Peter, Marcus ;   et al.
2002-07-25
Conjugate comprising an active agent, a polypeptide and a polyether
Grant 6,395,254 - Sinn , et al. May 28, 2
2002-05-28
p53 binding areas
App 20020042064 - Krammer, Peter ;   et al.
2002-04-11
Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
Grant 6,369,109 - Debatin , et al. April 9, 2
2002-04-09
Radiation detection device
Grant 6,310,352 - Gross , et al. October 30, 2
2001-10-30
Conjugate consisting of an active substance and a non-exogeneous native protein
App 20010012885 - Sinn, Hansjorg ;   et al.
2001-08-09
Radiation system with several radiation sources directed to a control point
Grant 6,259,762 - Pastyr , et al. July 10, 2
2001-07-10
Process for detecting specific antibodies acting against HPV proteins
Grant 6,214,541 - Zentgraf , et al. April 10, 2
2001-04-10
Metallocene-phosphoramidite conjugates, process for their preparation and their use
Grant 6,211,356 - Wiessler , et al. April 3, 2
2001-04-03
Preparation of acid amides and metallization of compounds
Grant 6,177,561 - Sinn , et al. January 23, 2
2001-01-23
Phagemid library for antibody screening
Grant 6,127,132 - Breitling , et al. October 3, 2
2000-10-03
Phagemid for antibody screening
Grant 5,985,588 - Breitling , et al. November 16, 1
1999-11-16
Phagemid for antibody screening
Grant 5,849,500 - Breitling , et al. December 15, 1
1998-12-15
Tumor inhibiting saccharide conjugates
Grant 5,622,936 - Wiessler , et al. April 22, 1
1997-04-22
Vaccine against Lyme disease
Grant 5,178,859 - Simon , et al. January 12, 1
1993-01-12

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