Patent | Date |
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Hydrocinnamoyl Protected Riboguanosine Phosphoramidites For Decreasing Depyrimidination From Alkyl Amine Exposure During Final Deprotection App 20220275019 - Lunstad; Benjamin D. ;   et al. | 2022-09-01 |
Compositions Comprising Chemically Modified Guide Rnas For Crispr/cas-mediated Editing Of Hbb App 20220195427 - Porteus; Matthew H. ;   et al. | 2022-06-23 |
Chemically Modified Guide Rnas For Crispr/cas-mediated Gene Correction App 20220195426 - Porteus; Matthew H. ;   et al. | 2022-06-23 |
Chemically Modified Guide Rnas For Crispr/cas-mediated Gene Regulation App 20220195425 - Porteus; Matthew H. ;   et al. | 2022-06-23 |
Chemically modified guide RNAs for CRISPR/CAS-mediated gene regulation Grant 11,306,309 - Porteus , et al. April 19, 2 | 2022-04-19 |
Orthoester compositions for affinity purification of oligonucleotides Grant 11,299,483 - Dellinger , et al. April 12, 2 | 2022-04-12 |
Phosphorous Protecting Groups And Methods Of Preparation And Use Thereof App 20220002334 - Dellinger; Douglas J. ;   et al. | 2022-01-06 |
Phosphorous protecting groups and methods of preparation and use thereof Grant 11,104,699 - Dellinger , et al. August 31, 2 | 2021-08-31 |
Guide Rna With Chemical Modifications App 20210079389 - RYAN; Daniel E. ;   et al. | 2021-03-18 |
Guide RNA with chemical modifications Grant 10,900,034 - Ryan , et al. January 26, 2 | 2021-01-26 |
High Specificity Genome Editing Using Chemically Modified Guide RNAs App 20200339980 - Dellinger; Douglas J ;   et al. | 2020-10-29 |
High specificity genome editing using chemically modified guide RNAs Grant 10,767,175 - Dellinger , et al. Sep | 2020-09-08 |
Orthoester Compositions For Affinity Purification Of Oligonucleotides App 20200190129 - DELLINGER; Douglas J. ;   et al. | 2020-06-18 |
Orthoester Compositions For Affinity Purification Of Oligonucleotides App 20200181124 - DELLINGER; Douglas J. ;   et al. | 2020-06-11 |
Protected monomer and method of final deprotection for RNA synthesis Grant 10,597,421 - Dellinger , et al. | 2020-03-24 |
Guide RNA with chemical modifications Grant 10,337,001 - Ryan , et al. | 2019-07-02 |
Phosphorous Protecting Groups And Methods Of Preparation And Use Thereof App 20190194242 - Dellinger; Douglas J. ;   et al. | 2019-06-27 |
Phosphorous protecting groups and methods of preparation and use thereof Grant 10,196,418 - Dellinger , et al. Fe | 2019-02-05 |
Protected Monomer And Method Of Final Deprotection For Rna Synthesis App 20180186826 - Dellinger; Douglas J. ;   et al. | 2018-07-05 |
Chemically Modified Guide RNAs for CRISPR/CAS-Mediated Gene Regulation App 20180119140 - Porteus; Matthew H. ;   et al. | 2018-05-03 |
Guide Rna With Chemical Modifications App 20180051281 - Ryan; Daniel E. ;   et al. | 2018-02-22 |
Protected monomer and method of final deprotection for RNA synthesis Grant 9,896,472 - Dellinger , et al. February 20, 2 | 2018-02-20 |
Preparation of long synthetic oligonucleotides by squarate conjugation chemistry Grant 9,890,190 - Hill , et al. February 13, 2 | 2018-02-13 |
High Specificity Genome Editing Using Chemically Modified Guide RNAs App 20170355985 - Dellinger; Douglas J. ;   et al. | 2017-12-14 |
Protecting groups for "Z nucleotide" and methods thereof Grant 9,802,975 - Lunstad , et al. October 31, 2 | 2017-10-31 |
Guide RNA with chemical modifications App 20160289675 - Ryan; Daniel E. ;   et al. | 2016-10-06 |
Preparation Of Long Synthetic Oligonucleotides By Squarate Conjugation Chemistry App 20160244820 - Hill; Kenneth W. ;   et al. | 2016-08-25 |
Protected monomer and method of final deprotection for RNA synthesis Grant 9,273,086 - Dellinger , et al. March 1, 2 | 2016-03-01 |
Protected Monomer and Method of Final Deprotection for RNA Synthesis App 20160002282 - DELLINGER; DOUGLAS J. ;   et al. | 2016-01-07 |
Protecting Groups For "Z Nucleotide" And Methods Thereof App 20150353594 - Lunstad; Benjamin D. ;   et al. | 2015-12-10 |
Phosphorous Protecting Groups And Methods Of Preparation And Use Thereof App 20150315227 - Dellinger; Douglas J. ;   et al. | 2015-11-05 |
Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide Grant 9,169,286 - Sierzchala , et al. October 27, 2 | 2015-10-27 |
Thiocarbon-protecting groups for RNA synthesis Grant 9,067,961 - Dellinger , et al. June 30, 2 | 2015-06-30 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge Grant 8,846,898 - Dellinger September 30, 2 | 2014-09-30 |
Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide Grant 8,642,755 - Sierzchala , et al. February 4, 2 | 2014-02-04 |
Solutions, methods, and processes for deprotection of polynucleotides Grant 8,552,174 - Dellinger , et al. October 8, 2 | 2013-10-08 |
Use Of N-alkyl Imidazole For Sulfurization Of Oligonucleotides With An Acetyl Disulfide App 20130035261 - Sierzchala; Agnieszka B. ;   et al. | 2013-02-07 |
Protected Monomer And Method Of Final Deprotection For Rna Synthesis App 20120289691 - Dellinger; Douglas J. ;   et al. | 2012-11-15 |
Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide Grant 8,309,710 - Sierzchala , et al. November 13, 2 | 2012-11-13 |
Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection Grant 8,309,706 - Dellinger , et al. November 13, 2 | 2012-11-13 |
Thiocarbon-protecting Groups For Rna Synthesis App 20120238737 - Dellinger; Douglas J. ;   et al. | 2012-09-20 |
Protecting groups for RNA synthesis Grant 8,242,258 - Dellinger , et al. August 14, 2 | 2012-08-14 |
Protected Monomers And Methods Of Deprotection For Rna Synthesis App 20120184724 - Sierzchala; Agnieszka B. ;   et al. | 2012-07-19 |
Thiocarbon-protecting groups for RNA synthesis Grant 8,202,983 - Dellinger , et al. June 19, 2 | 2012-06-19 |
Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection Grant 8,202,985 - Dellinger , et al. June 19, 2 | 2012-06-19 |
Thioether substituted aryl carbonate protecting groups Grant 8,097,711 - Timar , et al. January 17, 2 | 2012-01-17 |
2'-silyl containing thiocarbonate protecting groups for RNA synthesis Grant 7,999,087 - Dellinger , et al. August 16, 2 | 2011-08-16 |
Use Of N-Alkyl Imidazole For Sulfurization Of Oligonucleotides With An Acetyl Disulfide App 20100331532 - Sierzchala; Agnieszka B. ;   et al. | 2010-12-30 |
Use Of Thioacetic Acid Derivatives In The Sulfurization Of Oligonucleotides With Phenylacetyl Disulfide App 20100331533 - Sierzchala; Agnieszka B. ;   et al. | 2010-12-30 |
Cleavable thiocarbonate linkers for polynucleotide synthesis Grant 7,855,281 - Dellinger , et al. December 21, 2 | 2010-12-21 |
Phosphinoamidite Carboxylates and Analogs Thereof in the Synthesis of Oligonucleotide Having Reduced Internucleotide Charge App 20100311960 - DELLINGER; DOUGLAS J. | 2010-12-09 |
Thiocarbonate linkers for polynucleotides Grant 7,790,387 - Dellinger , et al. September 7, 2 | 2010-09-07 |
Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection Grant 7,759,471 - Dellinger , et al. July 20, 2 | 2010-07-20 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Grant 7,745,591 - Dellinger June 29, 2 | 2010-06-29 |
Protected Monomer And Method Of Final Deprotection For Rna Synthesis App 20100076183 - Dellinger; Douglas J. ;   et al. | 2010-03-25 |
Method of polynucleotide synthesis using modified support Grant 7,585,970 - Dellinger , et al. September 8, 2 | 2009-09-08 |
Thiocarbon-protecting Groups For Rna Synthesis App 20090209479 - Dellinger; Douglas J. ;   et al. | 2009-08-20 |
Cleavable linkers for polynucleotides Grant 7,572,908 - Dellinger , et al. August 11, 2 | 2009-08-11 |
Methods and compounds for polynucleotide synthesis Grant 7,572,907 - Dellinger , et al. August 11, 2 | 2009-08-11 |
Uses of cationic salts for polynucleotide synthesis Grant 7,524,950 - Dellinger , et al. April 28, 2 | 2009-04-28 |
Thiocarbonate linkers for polynucleotides App 20090082554 - Dellinger; Douglas J. ;   et al. | 2009-03-26 |
Methods and compositions for generating mixtures of nucleic acid molecules App 20090036660 - Myerson; Joel ;   et al. | 2009-02-05 |
Use of ionic liquids for fabrication of polynucleotide arrays Grant 7,435,810 - Myerson , et al. October 14, 2 | 2008-10-14 |
Precursors for two-step polynucleotide synthesis Grant 7,427,679 - Dellinger , et al. September 23, 2 | 2008-09-23 |
2'-silyl containing thiocarbonate protecting groups for RNA synthesis App 20080227964 - Dellinger; Douglas J. ;   et al. | 2008-09-18 |
Methods and compositions for DNA synthesis App 20080206850 - Dellinger; Douglas J. ;   et al. | 2008-08-28 |
Methods and compositions for RNA synthesis App 20080206851 - Dellinger; Douglas J. ;   et al. | 2008-08-28 |
Method for polynucleotide synthesis Grant 7,417,139 - Dellinger , et al. August 26, 2 | 2008-08-26 |
Protecting Groups for RNA Synthesis App 20080194502 - Dellinger; Douglas J. ;   et al. | 2008-08-14 |
Method of synthesizing polynucleotides using ionic liquids Grant 7,411,061 - Myerson , et al. August 12, 2 | 2008-08-12 |
Thioether substituted aryl carbonate protecting groups App 20080146787 - Timar; Zoltan ;   et al. | 2008-06-19 |
Cleavable linker for polynucleotide synthesis Grant 7,385,050 - Dellinger , et al. June 10, 2 | 2008-06-10 |
Phosphorus protecting groups Grant 7,368,550 - Dellinger , et al. May 6, 2 | 2008-05-06 |
Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection App 20080076913 - Dellinger; Douglas J. ;   et al. | 2008-03-27 |
Cleavable linkers for polynucleotides App 20070224603 - Dellinger; Douglas J. ;   et al. | 2007-09-27 |
Thiocarbonate linkers for polynucleotides App 20070224602 - Dellinger; Douglas J. ;   et al. | 2007-09-27 |
Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection App 20070100138 - Dellinger; Douglas J. ;   et al. | 2007-05-03 |
Solutions, methods, and processes for deprotection of polynucleotides App 20070100137 - Dellinger; Douglas J. ;   et al. | 2007-05-03 |
Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection App 20070100136 - Dellinger; Douglas J. ;   et al. | 2007-05-03 |
Phosphorus protecting groups App 20070099859 - Dellinger; Douglas J. ;   et al. | 2007-05-03 |
Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis Grant 7,193,077 - Dellinger , et al. March 20, 2 | 2007-03-20 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge App 20060293511 - Dellinger; Douglas J. | 2006-12-28 |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry Grant 7,135,565 - Dellinger , et al. November 14, 2 | 2006-11-14 |
Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection App 20060252924 - Dellinger; Douglas J. ;   et al. | 2006-11-09 |
Methods and compounds for polynucleotide synthesis App 20060247430 - Dellinger; Douglas J. ;   et al. | 2006-11-02 |
Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection Grant 7,101,986 - Dellinger , et al. September 5, 2 | 2006-09-05 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Grant 7,067,641 - Dellinger June 27, 2 | 2006-06-27 |
Uses of cationic salts for polynucleotide synthesis App 20050287555 - Dellinger, Douglas J. ;   et al. | 2005-12-29 |
MALDI-MS analysis of nucleic acids bound to a surface App 20050186579 - Dellinger, Douglas J. ;   et al. | 2005-08-25 |
Quality control method for array manufacture App 20050186580 - Dellinger, Douglas J. ;   et al. | 2005-08-25 |
Method of synthesizing polynucleotides using ionic liquids App 20050106685 - Myerson, Joel ;   et al. | 2005-05-19 |
Precursors for two-step polynucleotide synthesis App 20050049407 - Dellinger, Douglas J. ;   et al. | 2005-03-03 |
Method for polynucleotide synthesis App 20050048601 - Dellinger, Douglas J. ;   et al. | 2005-03-03 |
Method of polynucleotide synthesis using modified support App 20050048496 - Dellinger, Douglas J. ;   et al. | 2005-03-03 |
Cleavable linker for polynucleotide synthesis App 20050048497 - Dellinger, Douglas J. ;   et al. | 2005-03-03 |
Exocyclic amine triaryl methyl protecting groups in two step polynucleotide synthesis App 20050049411 - Dellinger, Douglas J. ;   et al. | 2005-03-03 |
Method of synthesizing polynucleotides using ionic liquids Grant 6,858,720 - Myerson , et al. February 22, 2 | 2005-02-22 |
Use of ionic liquids for fabrication of polynucleotide arrays Grant 6,852,850 - Myerson , et al. February 8, 2 | 2005-02-08 |
Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection App 20040230052 - Dellinger, Douglas J. ;   et al. | 2004-11-18 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge App 20040116687 - Dellinger, Douglas J. | 2004-06-17 |
Methods for preparing conjugates Grant 6,743,585 - Dellinger , et al. June 1, 2 | 2004-06-01 |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Grant 6,693,187 - Dellinger February 17, 2 | 2004-02-17 |
Monomers for solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection Grant 6,630,581 - Dellinger , et al. October 7, 2 | 2003-10-07 |
Use of ionic liquids for fabrication of polynucleotide arrays App 20030092904 - Myerson, Joel ;   et al. | 2003-05-15 |
Surface treatment method for bio-arrays App 20030082294 - Bruhn, Laurakay ;   et al. | 2003-05-01 |
Method of synthesizing polynucleotides using ionic liquids App 20030083489 - Myerson, Joel ;   et al. | 2003-05-01 |
Methods for generating ligand arrays via deposition of ligands onto olefin displaying substrates, and arrays produced thereby App 20030044798 - Lefkowitz, Steven M. ;   et al. | 2003-03-06 |
Functionalization of substrate surfaces with silane mixtures Grant 6,444,268 - Lefkowitz , et al. September 3, 2 | 2002-09-03 |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry App 20020058802 - Dellinger, Douglas J. ;   et al. | 2002-05-16 |
Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection App 20020045221 - Dellinger, Douglas J. ;   et al. | 2002-04-18 |
Methods for preparing conjugates App 20020025539 - Dellinger, Douglas J. ;   et al. | 2002-02-28 |
Functionalization of substrate surfaces with silane mixtures App 20010051221 - Lefkowitz, Steven M. ;   et al. | 2001-12-13 |
Methods for attaching substances to surfaces Grant 6,319,674 - Fulcrand , et al. November 20, 2 | 2001-11-20 |
Methods and devices for carrying out chemical reactions App 20010036641 - Gordon, Gary B. ;   et al. | 2001-11-01 |
Functionalization of substrate surfaces with silane mixtures Grant 6,258,454 - Lefkowitz , et al. July 10, 2 | 2001-07-10 |
Methods and devices for carrying out chemical reactions Grant 6,251,595 - Gordon , et al. June 26, 2 | 2001-06-26 |
Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection Grant 6,222,030 - Dellinger , et al. April 24, 2 | 2001-04-24 |
Signal enhancement method and kit Grant 6,110,682 - Dellinger , et al. August 29, 2 | 2000-08-29 |
Hybridization assay signal enhancement Grant 6,103,474 - Dellinger , et al. August 15, 2 | 2000-08-15 |
Method of amplifying the signal of target nucleic acid sequence analyte Grant 6,054,274 - Sampson , et al. April 25, 2 | 2000-04-25 |
Signal enhancement method and kit Grant 5,853,993 - Dellinger , et al. December 29, 1 | 1998-12-29 |
Copolymers of N-vinyl-lactams suitable for oligomer solid phase synthesis Grant 5,391,667 - Dellinger February 21, 1 | 1995-02-21 |