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NOTICE OF APPROVAL   OF EXTENSION REQUEST   MAILING DATE: Jan 28, 2005 A Notice of Allowance issued for the trademark application identified below on Dec 11, 2001.  The FIFTH request for extension of time to file a Statement of Use has been approved.  Applicant must continue to file extension requests every 6 months calculated from the date the Notice of Allowance was issued until a Statement of Use is filed.  Please note that a Statement of Use cannot be filed more than 36 months from the issuance date of the Notice of Allowance. For further information, visit our website at: http://www.uspto.gov or call the Trademark Assistance Center at 1-800-786-9199. SERIAL NUMBER: 76252353 MARK: TARCEVA OWNER: OSI Pharmaceuticals, Inc.

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UNITED STATES PATENT AND TRADEMARK OFFICE COMMISSIONER FOR TRADEMARKS P.O. BOX 1451 ALEXANDRIA, VA  22313-1451 FIRST-CLASS MAIL U.S POSTAGE PAID BARBARA GARGIULO OSI PHARMACEUTICALS INC STE 110 58 S SERVICE RD MELVILLE, NY   11747